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Pain mechanisms: a new theory.
A new theory of pain mechanisms is proposed, which holds that the nerve impulse pattern for pain is produced by intense stimulation of nonspecific receptors since "there are no specific fibers and no apecific endings". Expand
Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury
The identification of a specific population of neurons whose firing properties change suddenly and synchronously following axotomy, and whose activity is associated with tactile allodynia, provides a powerful vehicle for defining the specific cascade of cellular and molecular events that underlie neuropathic pain. Expand
Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats
The dorsal root ganglion with its ongoing activity and mechanical sensitivity could be a source of pain producing impulses and could particularly contribute to pain in those conditions of peripheral nerve damage where pain persists after peripheral anaesthesia or where vertebral manipulation is painful. Expand
Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
There is a spectrum of central changes in the stimulus response relations of the spinal cord resulting from the activation of C-fibers of different origins, which may be responsible for some of the sensory and motor alterations found after peripheral tissue injury. Expand
Autotomy following peripheral nerve lesions: experimental anesthesia dolorosa
The time course and degree of autotomy following various types of nerve injury in rats and mice is described and reasons are given to propose that autotomy is triggered by an abnormal afferent barrage generated in the cut end of the nerve. Expand
Temporary Abolition of Pain in Man
In eight patients with intense chronic cutaneous pain, sensory nerves or roots, square-wave 0.1-millisecond pulses at 100 cycles per second were applied and the voltage was raised until the patient reported tingling in the area, and pressure on previously sensitive areas failed to evoke pain. Expand
Responses of Single Dorsal Cord Cells to Peripheral Cutaneous Unmyelinated Fibres
An investigation of the response of cells in the dorsolateral tract of the cat to C fibres was carried out, finding that an afferent volley in the unmyelinated fibres led to a positive dorsal root potential as opposed to the well-known negative dorsal potential which is elicited by the large myelination fibres. Expand
Does the right side know what the left is doing?
Strong circumstantial evidence argues against a peripheral mechanism and in favour of a central mechanism, in particular signalling via the system of commissural interneurons that is present in spinal cord and brainstem, which could serve as a model system to study transmedian signalling systems. Expand