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Association of High Myopia with Crystallin Beta A4 (CRYBA4) Gene Polymorphisms in the Linkage-Identified MYP6 Locus
TLDR
A novel susceptibility gene (CRYBA4) was discovered for high myopia and signified the potential importance of appropriate gene prioritization in candidate selection.
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Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population
TLDR
Both SNPs could separately account for the association of NGA17 or NGA19, and that both SNPs contributed separate main effects to high myopia in the authors' family-based association study.
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Association of IGF1 gene haplotypes with high myopia in Chinese adults.
TLDR
IG1 haplotypes are associated with genetic susceptibility to high myopia in Chinese adults, whereas IGFBP3 and IGFBP4 are unlikely to be important in the genetic predisposition to highMyopia.
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Evaluation of proteoglycan gene polymorphisms as risk factors in the genetic susceptibility to high myopia.
TLDR
These six proteoglycan genes were not associated with high myopia in these Chinese subjects and hence are unlikely to be important in the genetic predisposition to highMyopia.
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TGFB1 as a susceptibility gene for high myopia: a replication study with new findings.
TLDR
TGFB1 is the first myopia susceptibility gene successfully replicated and the functional significance of rs4803455 or the genuine causative SNPs in linkage disequilibrium with it remains to be determined.
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PAX6 Haplotypes Are Associated with High Myopia in Han Chinese
TLDR
PAX6 haplotypes are associated with susceptibility to the development of high myopia in Chinese and an important role for rs12421026 is highlighted because haplotypes containing this SNP were found to be associated with highMyopia.
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A novel missense mutation in the NYX gene associated with high myopia
  • S. Yip, C. Li, M. Yap
  • Biology
    Ophthalmic & physiological optics : the journal…
  • 1 May 2013
TLDR
This work explored if NYX mutations could be associated with high myopia, but not CSNB1A, and found that it was unlikely that these mutations would cause severe myopia.
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Genetic Susceptibility to Refractive Error: Association of Vasoactive Intestinal Peptide Receptor 2 (VIPR2) with High Myopia in Chinese
TLDR
This is the first study to suggest a role of VIPR2 in the genetic susceptibility to high myopia, and EGR1, JUN, FOS and VIP are unlikely to be important in predisposing humans to highMyopia.
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Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2, and TIMP3 genes by a DNA pooling approach.
TLDR
MMP2, TIPM2, and TIMP3 genes were not associated with high myopia in this Chinese sample and hence are unlikely to play a major role in the genetic susceptibility to highMyopia.
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A DNA pooling-based case-control study of myopia candidate genes COL11A1, COL18A1, FBN1, and PLOD1 in a Chinese population
TLDR
Common polymorphisms in these four candidate genes (COL11A 1, COL18A1, FBN1 and PLOD1) were unlikely to play important roles in the genetic susceptibility to high myopia.
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