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Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa.
Polymorphisms of the IL-1B and IL-1RN genes (which encode interleukin [IL]-1beta and IL-1 receptor antagonist, respectively) have been associated with hypochlorhydria and gastric cancer. WeExpand
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Enterochromaffin cells of the human gut: sensors for spices and odorants.
BACKGROUND & AIMS Release of serotonin from mucosal enterochromaffin cells triggered by luminal substances is the key event in the regulation of gut motility and secretion. We were interested to knowExpand
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Extracellular and intracellular pattern recognition receptors cooperate in the recognition of Helicobacter pylori.
BACKGROUND & AIMS Helicobacter pylori infects half of the world's population, thereby causing significant human morbidity and mortality. The mechanisms by which professional antigen-presenting cellsExpand
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Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccination.
Helicobacter pylori colonizes the human gastric mucosa and is associated with specific gastric disease. Virulence factors, such as urease, the vacuolating toxin (VacA), the cytotoxin-associatedExpand
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Inhibition of T-Cell Proliferation by Helicobacter pylori γ-Glutamyl Transpeptidase
Background & Aims: Helicobacter pylori colonizes the human gastric mucosa of >50% of the world’s population. Most of the patients have no overt clinical symptoms. However, the infection is invariablyExpand
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Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase.
BACKGROUND & AIMS Helicobacter pylori colonizes the human gastric mucosa of >50% of the world's population. Most of the patients have no overt clinical symptoms. However, the infection is invariablyExpand
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Human Dendritic Cells Respond to Helicobacter pylori, Promoting NK Cell and Th1-Effector Responses In Vitro1
Helicobacter pylori infection leads to chronic gastric inflammation. The current study determined the response of human APCs, NK cells, and T cells toward the bacteria in vitro. HumanExpand
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Antigenic Properties of HpaA and Omp18, Two Outer Membrane Proteins of Helicobacter pylori
ABSTRACT Outer membrane proteins (OMPs) are incorporated into the outer plasma membrane of Helicobacter pylori and are important for, e.g., ion transport, adherence, structural and osmotic stability,Expand
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cDNA cloning and characterization of a novel 16 kDa protein located in zymogen granules of rat pancreas and goblet cells of the gut.
By immunoscreening of a cDNA expression library of rat pancreas with a polyspecific antibody to purified rat zymogen granule membranes, we have cloned a cDNA coding for a novel protein of about 16Expand
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Correlation of the Helicobacter pylori adherence factor BabA with duodenal ulcer disease in four European countries.
Helicobacter pylori strains harboring the vacAs1, cagA and babA2 have been associated with ulcer disease (UD). We compared the prevalence of these different genotypes and adhesive properties in H.Expand
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