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Periodontal Disease and Cardiovascular Disease.
It is our central hypothesis that periodontal diseases, which are chronic Gramnegative infections, represent a previously unrecognized risk factor for atherosclerosis and thromboembolic events.Expand
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Effects of Air Pollution on Heart Rate Variability: The VA Normative Aging Study
Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameterExpand
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Rapid DNA methylation changes after exposure to traffic particles.
RATIONALE Exposure to particulate air pollution has been related to increased hospitalization and death, particularly from cardiovascular disease. Lower blood DNA methylation content is found inExpand
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Epigenetic Signatures of Cigarette Smoking
Background—DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers,Expand
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Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis.
BACKGROUND Estimates of global DNA methylation from repetitive DNA elements, such as Alu and LINE-1, have been increasingly used in epidemiological investigations because of their relative low-cost,Expand
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Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study.
CONTEXT Various correlates of posttraumatic stress disorder (PTSD), such as high levels of sympathetic activation and hypothalamic-pituitary-adrenal axis dysregulation, have been linked to arterialExpand
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Is the Glass Half Empty or Half Full? A Prospective Study of Optimism and Coronary Heart Disease in the Normative Aging Study
Objective A sense of optimism, which derives from the ways individuals explain causes of daily events, has been shown to protect health, whereas pessimism has been linked to poor physical health. WeExpand
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Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by-environment interaction.
RATIONALE Air pollution by particulate matter (PM) has been associated with cardiovascular deaths, although the mechanism of action is unclear. One proposed pathway is through disturbances of theExpand
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Is worrying bad for your heart? A prospective study of worry and coronary heart disease in the Normative Aging Study.
BACKGROUND Worry is an important component of anxiety, which recent work suggests is related to increased incidence of coronary heart disease (CHD). Chronic worry has also been associated withExpand
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Ischemic Heart Disease and Stroke in Relation to Blood DNA Methylation
Background: Epigenetic features such as DNA hypomethylation have been associated with conditions related to cardiovascular risk. We evaluated whether lower blood DNA methylation in heavily methylatedExpand
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