P. Vihko

Publications200
h-index56
Citations8,374
Highly Influential Citations293
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Prostatic Acid Phosphatase Is an Ectonucleotidase and Suppresses Pain by Generating Adenosine
View on Elsevier
Colorectal carcinoma associated with serrated adenoma – prevalence, histological features, and prognosis
TLDR
It is concluded that carcinoma associated with serrated adenoma is a distinct type of colorectal neoplasm, accounting for 5.8% of all coloreCTal carcinoma cases in this study.
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Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
  • J. Elo, L. Kvist, P. Vihko
  • Biology, Medicine
    The Journal of clinical endocrinology and…
  • 1 December 1995
TLDR
The mutated receptor was activated by estradiol to a significantly greater extent than the wild-type receptor, and the AR gene mutation might be one explanation for the altered biological activity of prostatic cancer.
View on PubMed
Intracellular Machinery for Matrix Degradation in Bone‐Resorbing Osteoclasts
In osteoclasts, TRACP co‐localized with cathepsin K in transcytotic vesicles and was activated by cathepsin K in vitro, suggesting that TRACP may degrade organic matrix components in transcytotic…
View on Wiley
Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase*
TLDR
It is shown that TRAP can generate ROS in vitro and that cells over-expressing TRAP produce higher amounts of intracellular ROS than their parent cells, and proposed that proteins containing redox-active iron could represent a novel mechanism of physiological fragmentation of organic molecules.
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Detection of hematogenous micrometastasis in patients with prostate cancer.
TLDR
Contrary to a long held hypothesis, these data point to the possibility that hematogenous metastasis may be a relatively early event in the natural history of human prostate cancer.
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Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7.
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Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.
TLDR
Cl cloning of mouse 17 beta-HSD type-1 cDNA from an ovarian library generated from 4,4'-(1,2-diethyl-1, 2-ethenediyl)bisphenol-( diethylstilbestrol)-tr eated mice, and characterization of the corresponding enzyme are described.
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Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase
View on Wiley
O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.
TLDR
It is found that galectin-1-expressing prostate cancer cells killed bound T cells, whereas LNCaP cells that do not express galectIn-1 did not kill T cells.
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