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Colorectal carcinoma associated with serrated adenoma – prevalence, histological features, and prognosis
It is concluded that carcinoma associated with serrated adenoma is a distinct type of colorectal neoplasm, accounting for 5.8% of all coloreCTal carcinoma cases in this study.
Mutated human androgen receptor gene detected in a prostatic cancer patient is also activated by estradiol.
  • J. Elo, L. Kvist, P. Vihko
  • Biology, Medicine
    The Journal of clinical endocrinology and…
  • 1 December 1995
The mutated receptor was activated by estradiol to a significantly greater extent than the wild-type receptor, and the AR gene mutation might be one explanation for the altered biological activity of prostatic cancer.
Intracellular Machinery for Matrix Degradation in Bone‐Resorbing Osteoclasts
In osteoclasts, TRACP co‐localized with cathepsin K in transcytotic vesicles and was activated by cathepsin K in vitro, suggesting that TRACP may degrade organic matrix components in transcytotic
Intracellular Fragmentation of Bone Resorption Products by Reactive Oxygen Species Generated by Osteoclastic Tartrate-resistant Acid Phosphatase*
It is shown that TRAP can generate ROS in vitro and that cells over-expressing TRAP produce higher amounts of intracellular ROS than their parent cells, and proposed that proteins containing redox-active iron could represent a novel mechanism of physiological fragmentation of organic molecules.
Detection of hematogenous micrometastasis in patients with prostate cancer.
Contrary to a long held hypothesis, these data point to the possibility that hematogenous metastasis may be a relatively early event in the natural history of human prostate cancer.
Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.
Cl cloning of mouse 17 beta-HSD type-1 cDNA from an ovarian library generated from 4,4'-(1,2-diethyl-1, 2-ethenediyl)bisphenol-( diethylstilbestrol)-tr eated mice, and characterization of the corresponding enzyme are described.
O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.
It is found that galectin-1-expressing prostate cancer cells killed bound T cells, whereas LNCaP cells that do not express galectIn-1 did not kill T cells.