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An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation
The transcription factor AP-1 plays key roles in tumorigenesis, by regulating a variety of protein-coding genes, implicated in multiple hallmarks of cancer. Among non-coding genes, no AP-1 target hasExpand
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Identification of microRNA-regulated gene networks by expression analysis of target genes.
MicroRNAs (miRNAs) and transcription factors control eukaryotic cell proliferation, differentiation, and metabolism through their specific gene regulatory networks. However, differently fromExpand
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Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative
Mouse embryonic stem (ES) glucose-6-phosphate (G6P) dehydrogenase-deleted cells ( G6pd delta), obtained by transient Cre recombinase expression in a G6pd -loxed cell line, are unable to produce G6PExpand
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A regulatory element that mediates co‐operation between a PEA3‐AP‐1 element and an AP‐1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells.
We have characterized a transcriptional enhancer of the human urokinase‐type plasminogen activator (uPA) gene and found a regulatory element required for co‐operation between a PEA3‐‐AP‐1 element andExpand
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A novel complex between the p65 subunit of NF‐kappa B and c‐Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.
The NF‐kappa B subunits, p50 and p65, have extensive sequence homology with the c‐rel proto‐oncogene and the Drosophila morphogen dorsal. It has recently been shown that in vitro translated c‐Rel canExpand
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miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer
MicroRNAs (miRNAs) control cell cycle progression by targeting the transcripts encoding for cyclins, CDKs and CDK inhibitors, such as p27KIP1 (p27). p27 expression is controlled by multipleExpand
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Urokinase Plasminogen Activator Receptor Affects Bone Homeostasis by Regulating Osteoblast and Osteoclast Function
The uPAR and its ligand uPA are expressed by both osteoblasts and osteoclasts. Their function in bone remodeling is unknown. We report that uPAR‐lacking mice display increased BMD, increasedExpand
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An upstream enhancer and a negative element in the 5' flanking region of the human urokinase plasminogen activator gene.
The 5' flanking region of the human urokinase (uPA) gene has been fused to the reporter chloramphenicol acetyl transferase (CAT) gene and its activity assayed by transfection in two human cell lines.Expand
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Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.
Human urokinase cDNA clones have been identified from a cDNA library prepared from total RNA of human fibroblasts transformed by simian virus 40 [Okayama, H. & Berg, P. (1983) Mol. Cell. Biol. 3,Expand
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Heterodimerization of c-Jun with ATF-2 and c-Fos is required for positive and negative regulation of the human urokinase enhancer.
Dimerization plays a pivotal role in modulating the activity of the c-Jun proto-oncogene product. Heterodimerization with activating transcription factor-2 (ATF-2) alters the DNA-binding specificityExpand
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