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Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of…
TLDR
The plasma assay was validated for parameters such as specificity, accuracy and extraction recovery, and can be extended for routine analysis of anti-diabetics in pharmaceutical preparations and in biological matrices.
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Influence of cholestyramine on the pharmacokinetics of rosiglitazone and its metabolite, desmethylrosiglitazone, after oral and intravenous dosing of rosiglitazone: Impact on oral bioavailability,…
TLDR
A systematic investigation demonstrating mechanistically the interaction potential of RGL when co-administered with CSA is demonstrated and the applicability of the metabolite data after intravenous and oral dosing and pH-based binding experiments adds credence to the key findings.
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Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: Do adenosine A1 antagonists (selective/non-selective) normalize the altered…
TLDR
The pharmacokinetic disposition of TPT improved considerably upon treatment with DPPX, a selective adenosine A1 antagonist, and may be involved in the tubular secretory pathway when a passive glomerular filtration pathway for elimination was not possible.
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Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): Optimization of the duration of UN dosing
TLDR
It is concluded that 3 days UN dosing was sufficient to induce ARF in rats, and that the dose of etoposide required needs to be monitored due to altered PK.
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BIOANALYTICAL METHOD DEVELOPMENT AND COMPARATIVE BIOAVAILABILITY STUDY OF CLOBAZAM TABLETS IN ALBINO RATS PLASMA USING RP-HPLC METHOD
A rapid and specific bioanalytical method was developed for clobazam (100 mg) in albino rat plasma using ibuprofen as an internal standard (IS) and bioequivalence study has also been carried out on…
Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid®
TLDR
Plasma levels of DRF-6196 were lesser compared to linezolid in the initial hours, it may not have any consequences on the clinical effectiveness of the molecule and absolute oral bioavailability was found to be 80–96% across the test dose range.
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