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Eosinophilic inflammation in asthma.
TLDR
Eosinophilic inflammation of the airways is correlated with the severity of asthma and these cells are likely to play a part in the epithelial damage seen in this disease. Expand
Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease.
TLDR
Elevated levels of troponin T and C-reactive protein are strongly related to the long-term risk of death from cardiac causes and these markers are independent risk factors, and their effects are additive with respect to each other and other clinical indicators of risk. Expand
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers.
TLDR
The heterogeneity of the biologic response of COPD exacerbations can be defined and biomarkers that differentiated clinical exacerbation phenotypes were investigated, including sputum IL-1β, serum CXCL10, and peripheral eosinophils are biomarkers of bacteria-, virus-, or eos inophil-associated exacerbations of COPd. Expand
The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies.
TLDR
In the absence of diagnostic increases in serum creatinine, NGAL detects patients with likely subclinical AKI who have an increased risk of adverse outcomes and the concept and definition of AKI might need re-assessment. Expand
Recommendations for the use of cardiac troponin measurement in acute cardiac care.
TLDR
The Working Group on Acute Cardiac Care of the European Society of Cardiology established a committee to deal with ongoing and newly developing issues related to cardiac biomarkers, to outline the principles for the application of various biomarkers by clinicians in the setting of acute cardiac care in a series of expert consensus documents. Expand
N‐Terminal Pro‐Brain Natriuretic Peptide and Other Risk Markers for the Separate Prediction of Mortality and Subsequent Myocardial Infarction in Patients With Unstable Coronary Artery Disease: A
TLDR
The use of N‐terminal pro‐brain natriuretic peptide appears to add critical prognostic insight to the assessment of patients with ACS, and the combination of NT‐proBNP and creatinine clearance provided the best prediction. Expand
Cytokine‐regulated accumulation of eosinophils in inflammatory disease
TLDR
The aim of this paper is to review the role of cytokines in the process of eosinophil recruitment in asthma, allergy and ulcerative colitis. Expand
How to use high-sensitivity cardiac troponins in acute cardiac care
TLDR
It is advocated that cTn assays should be labelled ‘high-sensitive’ only if they fulfil the analytical criteria suggested by the authors based on the limited evidence available at this time. Expand
Multicenter analytical evaluation of a high-sensitivity troponin T assay.
TLDR
The Roche hscTnT assay conforms to guideline precision requirements and will likely identify additional patients with myocardial injury suspicious for AMI in a multicenter, international trial. Expand
Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial.
TLDR
The peripheral blood eosinophil count is a promising biomarker to direct corticosteroid therapy during COPD exacerbations, but larger studies are required. Expand
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