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The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis.
- C. Seers, N. Slakeski, +4 authors E. Reynolds
- Biology, Medicine
- Journal of bacteriology
- 1 September 2006
Porphyromonas gingivalis produces outer membrane-attached proteins that include the virulence-associated proteinases RgpA and RgpB (Arg-gingipains) and Kgp (Lys-gingipain). We analyzed the P.… Expand
Protein substrates of a novel secretion system are numerous in the Bacteroidetes phylum and have in common a cleavable C-terminal secretion signal, extensive post-translational modification, and…
- P. Veith, N. A. Nor Muhammad, +6 authors E. Reynolds
- Biology, Medicine
- Journal of proteome research
- 23 September 2013
The secretion of certain proteins in Porphyromonas gingivalis is dependent on a C-terminal domain (CTD). After secretion, the CTD is cleaved prior to extensive modification of the mature protein,… Expand
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.
- P. Veith, G. H. Talbo, +4 authors E. Reynolds
- Biology, Medicine
- The Biochemical journal
- 1 April 2002
Porphyromonas gingivalis is an anaerobic, asaccharolytic Gram-negative rod associated with chronic periodontitis. We have undertaken a proteomic study of the outer membrane of P. gingivalis strain… Expand
PG0026 Is the C-terminal Signal Peptidase of a Novel Secretion System of Porphyromonas gingivalis♦
- M. Glew, P. Veith, +8 authors E. Reynolds
- Biology, Medicine
- The Journal of Biological Chemistry
- 16 May 2012
Background: Several virulence factors of Porphyromonas gingivalis have a novel C-terminal signal that directs secretion across the outer membrane. Results: The predicted catalytic amino acid of… Expand
The outer membrane protein LptO is essential for the O‐deacylation of LPS and the co‐ordinated secretion and attachment of A‐LPS and CTD proteins in Porphyromonas gingivalis
- Y. Chen, B. Peng, +8 authors E. Reynolds
- Biology, Medicine
- Molecular microbiology
- 1 March 2011
Protein substrates of a novel secretion system of Porphyromonas gingivalis contain a conserved C‐terminal domain (CTD) essential for secretion and attachment to the cell surface. Inactivation of lptO… Expand
Identification of a New Membrane-associated Protein That Influences Transport/Maturation of Gingipains and Adhesins of Porphyromonas gingivalis*
- Keiko Sato, E. Sakai, +8 authors K. Nakayama
- Biology, Medicine
- Journal of Biological Chemistry
- 11 March 2005
The dual membrane envelopes of Gram-negative bacteria provide two barriers of unlike nature that regulate the transport of molecules into and out of organisms. Organisms have developed several… Expand
A Novel Porphyromonas gingivalis FeoB Plays a Role in Manganese Accumulation*
- S. Dashper, C. A. Butler, +7 authors E. Reynolds
- Biology, Medicine
- Journal of Biological Chemistry
- 29 July 2005
FeoB is an atypical transporter that has been shown to exclusively mediate ferrous ion transport in some bacteria. Unusually the genome of the periodontal pathogen Porphyromonas gingivalis has two… Expand
Mass spectrometric analyses of peptides and proteins in human gingival crevicular fluid.
- L. Ngo, P. Veith, Y. Chen, D. Chen, I. Darby, E. Reynolds
- Chemistry, Medicine
- Journal of proteome research
- 22 January 2010
Gingival crevicular fluid (GCF) is a pathophysiological fluid that flows into the oral cavity. Human GCF was collected using sterile glass microcapillary tubes from inflamed periodontal sites in… Expand
Porphyromonas gingivalis outer membrane vesicles exclusively contain outer membrane and periplasmic proteins and carry a cargo enriched with virulence factors.
- P. Veith, Y. Chen, +6 authors E. Reynolds
- Biology, Medicine
- Journal of proteome research
- 3 April 2014
Porphyromonas gingivalis, a keystone pathogen associated with chronic periodontitis, produces outer membrane vesicles (OMVs) that carry a cargo of virulence factors. In this study, the proteome of… Expand
An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone Loss1
- N. O'Brien-Simpson, Rishi D. Pathirana, +6 authors E. Reynolds
- Chemistry, Medicine
- The Journal of Immunology
- 15 September 2005
Porphyromonas gingivalis, a pathogen associated with periodontitis, bound to fibrinogen, fibronectin, hemoglobin, and collagen type V with a similar profile to that of its major virulence factor, the… Expand