Ultraviolet irradiation doses for coronavirus inactivation – review and analysis of coronavirus photoinactivation studies
- M. Hessling, Katharina Hönes, P. Vatter, C. Lingenfelder
- Medicine, BiologyGMS Hygiene and Infection Control
- 14 May 2020
Since coronaviruses do not differ structurally to any great exent, the SARS-CoV-2 virus – as well as possible future mutations – will very likely be highly UV sensitive, so that common UV disinfection procedures will inactivate the new SARS-CoVs without any further modification.
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.
- Thomas Piechulek, Tobias Rehlen, Claudia Walliser, P. Vatter, B. Moepps, P. Gierschik
- Biology, Computer ScienceJournal of Biological Chemistry
- 2005
The results suggest a novel mechanism of PLCgamma(2) activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP(3).
Biologically inactive leptin and early-onset extreme obesity.
- M. Wabitsch, J. Funcke, P. Fischer-Posovszky
- BiologyNew England Journal of Medicine
- 2015
Treating a 2-year-old boy with early-onset extreme obesity due to a novel homozygous transversion in LEP with recombinant human leptin (metreleptin) rapidly normalized eating behavior and resulted in weight loss.
Constitutive serum response factor activation by the viral chemokine receptor homologue pUS28 is differentially regulated by Galpha(q/11) and Galpha(16).
- B. Moepps, C. Tulone, P. Gierschik
- BiologyCellular Signalling
- 1 August 2008
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
- T. D. Bunney, O. Opaleye, M. Katan
- BiologyMolecules and Cells
- 24 April 2009
Isozyme-specific Stimulation of Phospholipase C-γ2 by Rac GTPases*♦
- Thomas Piechulek, Tobias Rehlen, Claudia Walliser, P. Vatter, B. Moepps, P. Gierschik
- Biology, ChemistryJournal of Biological Chemistry
- 25 November 2005
The results suggest a novel mechanism of PLCγ2 activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP3.
The variable C‐terminal extension of G‐protein‐coupled receptor kinase 6 constitutes an accessorial autoregulatory domain
- P. Vatter, C. Stoesser, Ines Samel, P. Gierschik, B. Moepps
- BiologyThe FEBS Journal
- 1 December 2005
The results suggest that mGRK6‐C may be considered a basic, prototypic representative of the GRK4‐like kinases, which is capable of interacting with both plasma membrane and its receptor substrate, but is resistant to further regulatory modification conferred to the prototype via C‐terminal extension.
Rac Regulates Its Effector Phospholipase Cγ2 through Interaction with a Split Pleckstrin Homology Domain*S⃞
- Claudia Walliser, Michael Retlich, T. D. Bunney
- Biology, Computer ScienceJournal of Biological Chemistry
- 31 October 2008
It is shown that an unusual pleckstrin homology (PH) domain, designated as the split PH domain (spPH), is both necessary and sufficient to effect activation of PLCγ2 by Rac2, and that Rac2 directly binds to P LCγ2 as well as to the isolated spPH of this isoform.
Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase Cγ2
- K. L. Everett, Anja Buehler, M. Katan
- Biology, Computer ScienceMolecular and Cellular Biology
- 18 January 2011
Analysis of the molecular mechanisms involved in the regulation of phospholipase Cγ2 suggest that membrane proximity, on its own or together with Rac2, has a role in the release of autoinhibition, resulting in interfacial activation.
The impact of far-UVC radiation (200–230 nm) on pathogens, cells, skin, and eyes – a collection and analysis of a hundred years of data
- M. Hessling, Robin Haag, N. Sieber, P. Vatter
- MedicineGMS Hygiene and Infection Control
- 16 February 2021
Far-UVC radiation, especially the 222 nm emission of KrCl excimer lamps, exhibits strong antimicrobial properties and may be suitable for future technological approaches for decontamination in rooms in the presence of people or for antisepsis.
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