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Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.
TLDR
The results suggest a novel mechanism of PLCgamma(2) activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP(3).
Ultraviolet irradiation doses for coronavirus inactivation – review and analysis of coronavirus photoinactivation studies
TLDR
Since coronaviruses do not differ structurally to any great exent, the SARS-CoV-2 virus – as well as possible future mutations – will very likely be highly UV sensitive, so that common UV disinfection procedures will inactivate the new SARS-CoVs without any further modification.
Constitutive serum response factor activation by the viral chemokine receptor homologue pUS28 is differentially regulated by Galpha(q/11) and Galpha(16).
TLDR
It is demonstrated that expression of pUS28 in COS-7 cells caused a vigorous induction of SRF activity, and was specifically mediated by endogenous G(q) and/or G(11) as well as RhoA and/ or a closely related Rho GTPase.
Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase Cγ2
TLDR
Analysis of the molecular mechanisms involved in the regulation of phospholipase Cγ2 suggest that membrane proximity, on its own or together with Rac2, has a role in the release of autoinhibition, resulting in interfacial activation.
Biologically inactive leptin and early-onset extreme obesity.
TLDR
Treating a 2-year-old boy with early-onset extreme obesity due to a novel homozygous transversion in LEP with recombinant human leptin (metreleptin) rapidly normalized eating behavior and resulted in weight loss.
The variable C‐terminal extension of G‐protein‐coupled receptor kinase 6 constitutes an accessorial autoregulatory domain
TLDR
The results suggest that mGRK6‐C may be considered a basic, prototypic representative of the GRK4‐like kinases, which is capable of interacting with both plasma membrane and its receptor substrate, but is resistant to further regulatory modification conferred to the prototype via C‐terminal extension.
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
TLDR
This work presents the crystal structure of the complex of Rac2 bound to the split pleckstrin homology (spPH) domain of phospholipase C-gamma(2) (PLCgamma) and highlights the role of effector binding as a common feature of Rac and Cdc42 interactions with a variety of effectors.
Isozyme-specific Stimulation of Phospholipase C-γ2 by Rac GTPases*♦
TLDR
The results suggest a novel mechanism of PLCγ2 activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP3.
Rac Regulates Its Effector Phospholipase Cγ2 through Interaction with a Split Pleckstrin Homology Domain*S⃞
TLDR
It is shown that an unusual pleckstrin homology (PH) domain, designated as the split PH domain (spPH), is both necessary and sufficient to effect activation of PLCγ2 by Rac2, and that Rac2 directly binds to P LCγ2 as well as to the isolated spPH of this isoform.
LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways.
TLDR
This work is the first positive demonstration of a stimulatory effect of LARG on the ability of a strictly G(q)-coupled receptor to cause activation of a Rho-GTPase-dependent signaling pathway.
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