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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease. Expand
Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption*
The properties of a calcium transport protein (CaT1) cloned from rat duodenum using an expression cloning strategy in Xenopus laevis oocytes are reported, which likely plays a key role in the intestinal uptake of calcium. Expand
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
The results raise the possibility that the preclinical and early clinical progression of AD is driven in part by the accumulation of specific Aβ assembly intermediates formed during the process of fibrillogenesis, and suggest that PF have inherent biological activity similar to that of mature fibrils. Expand
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney and the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins. Expand
Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism.
There is a variable, but substantial, reduction in the immunoreactivity of the Ca2+o-sensing receptor protein in both parathyroid adenomas and uremic hyperparathyroidism, as assessed by immunohistochemistry, that probably results from reduced expression of the receptor protein and may contribute to the increase in the set-point often observed in these patients. Expand
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions
It is shown that polycystin-L is a calcium-modulated nonselective cation channel that is permeable to sodium, potassium and calcium ions and may act as a transducer of calcium-mediated signalling in vivo. Expand
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease.
It is shown that PC2 is a Ca(2+)-permeable cation channel with properties distinct from any known intracellular channels, and that it can be translocated to the plasma membranes by defined chemical chaperones and proteasome modulators, suggesting that in vivo, it may also function in the plasma membrane under specific conditions. Expand
Human calcium transport protein CaT1.
A role for hCaT1 in cellular calcium uptake in a variety of tissues, including the transcellular calcium transport pathway in intestine, is suggested. Expand
The Ca2+-sensing receptor: a target for polyamines.
  • S. Quinn, C. Ye, +4 authors E. Brown
  • Biology, Medicine
  • American journal of physiology. Cell physiology
  • 1 October 1997
Data suggest that polyamines could be effective agonists for the CaR, and several tissues, including the brain, may use theCaR as a target for the actions of spermine and other endogenous polycationic agonists. Expand
Native Polycystin 2 Functions as a Plasma Membrane Ca2+-Permeable Cation Channel in Renal Epithelia
Results show that PC2 functions as a plasma membrane channel in renal epithelia and suggest that PC1 contributes to Ca2+ entry and transport of other cations in defined nephron segments in vivo and generate and characterized a polyclonal antibody against PC2. Expand