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Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury.
The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in theExpand
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A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve, modulates the immune system in the spleen. Vagus nerve stimulationExpand
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Review article: the role of gastric motility in the control of food intake
Aliment Pharmacol Ther 2011; 33: 880–894
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Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system
Enteric glial cells are vital for the autonomic control of gastrointestinal homeostasis by the enteric nervous system. Several different functions have been assigned to enteric glial cells butExpand
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HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause bothExpand
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Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.
BACKGROUND & AIMS Histamine sensitizes the nociceptor transient reporter potential channel V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We investigated theExpand
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Activity‐dependent regulation of tyrosine hydroxylase expression in the enteric nervous system
The regulation of neuromediator expression by neuronal activity in the enteric nervous system (ENS) is currently unknown. Using primary cultures of ENS derived from rat embryonic intestine, we haveExpand
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Imaging neuron-glia interactions in the enteric nervous system
The enteric nervous system (ENS) is a network of neurons and glia within the wall of the gastrointestinal tract that is able to control many aspects of digestive function independently from theExpand
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Characterization of myenteric neuropathy in the jejunum of spontaneously diabetic BB‐rats
Abstract  Decreased gastric expression and function of neuronal nitric oxide synthase (nNOS) has been proposed as a potential mechanism underlying diabetic gastroparesis. As gastric nNOS expressionExpand
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A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity
Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developedExpand
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