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Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology
The synthesis of a novel series of epoxy-endoperoxides that can be prepared in high yields from simple starting materials are reported on and suggest that the digestive vacuole is an important initial site of endoperoxide antimalarial activity. Expand
Kinetically controlled porosity in a robust organic cage material.
The synthesis and characterization of a novel, permanently porous, shape-persistent cage molecule (C1) is described that is constructed entirely from thermodynamically robust carbon–carbon bonds and has the molecular formula C112H62O2 (Scheme 1). Expand
Synthesis and chemistry of 2,3-dioxabicyclo[2.2.2]octane-5,6-diols.
During the study of the chemistry of 2,3-dioxabicyclo[ 2.2.2]octane-5,6-diols a hitherto unknown rearrangement was discovered which has wide applicability for the synthesis of 1,4-dicarbonyls, including optically enriched synthons. Expand
Continuous flow synthesis of a carbon-based molecular cage macrocycle via a three-fold homocoupling reaction.
The facile synthesis of the cage molecule (C110H56Br2) via a remarkable three-fold homo-coupling macrocyclization reaction using continuous flow methodology is reported, which improves the residence time, safety, and environmental profile of this synthetically challenging reaction. Expand
Endohedrally functionalised porous organic cages.
It is demonstrated that a step-wise approach to the synthesis of these robust C-C bonded cages allows for the introduction of a controlled number of endohedral pyridine functional groups. Expand
External Coordination of Europium(III) Prior to Its Encapsulation within a Cyclen-Based Pendant Donor Macrocycle
Evidence has been obtained for the precoordination of europium(III) to the eight pendant hydroxyl groups of two cyclen-derived macrocycles prior to its penetration into the four oxygen donor and fourExpand
Diastereomeric Δ-1,4,7,10-Tetrakis((R)-2-hydroxy-2-phenylethyl)- 1,4,7,10-tetraazacyclododecane and Its Alkali-Metal Complex Ions. A Potentiometric Titration, Nuclear Magnetic Resonance, and
13C NMR studies are consistent with Δ-1,4,7,10-tetrakis((R)-2-hydroxy-2-phenylethyl)-1,4,7,10-tetraazacyclododecane (ΔR-thpec12) and its eight-coordinate alkali-metal complexes, Δ[M(R-thpec12)]+,Expand
Enantiomerization of pendant-arm triaza macrocyclic lithium(I) and sodium(I) complex ions.
The first reported enantiomerization of six-coordinate alkali metal complex ions, represented by 1,4,7-tris(2-hydroxyethyl)-1,4,7-triazacyclononanelithium(I) and its sodium(I) analogue in methanol,Expand
Lost and Found Times, No. 37