• Publications
  • Influence
A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains (*)
The synovial fluid or group II secretory phospholipase A2 (sPLA2) has been implicated as an important agent involved in a number of inflammatory processes. In an attempt to determine the role ofExpand
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Phospholipase A2--a mediator between proximal and distal effectors of inflammation.
Phospholipase A2 (PLA2) is known to play an important intracellular role in inflammatory processes but does it also perform a vital function extracellularly? Here, W. Pruzanski and P. Vadas marshallExpand
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Factors affecting the determination of threshold doses for allergenic foods: how much is too much?
BACKGROUND Ingestion of small amounts of an offending food can elicit adverse reactions in individuals with IgE-mediated food allergies. The threshold dose for provocation of such reactions is oftenExpand
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Anaphylaxis: mechanisms and management
  • J. Lee, P. Vadas
  • Medicine
  • Clinical and experimental allergy : journal of…
  • 1 July 2011
Anaphylaxis is a serious allergic reaction that can be rapid in onset and occasionally fatal. This is a review of the literature on the epidemiology of anaphylaxis, diagnostic criteria, mechanisms,Expand
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A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much?
Background While the ingestion of small amounts of an offending food can elicit adverse reactions in individuals with IgE‐mediated food allergies, little information is known regarding theseExpand
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Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid.
Synovial fluid from arthritic patients contains multiple forms of phospholipase A2 (PLA2), as resolved by high performance liquid chromatography (Seilhamer, J.J., Plant, S., Pruzanski, W., Schilling,Expand
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Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis.
BACKGROUND Platelet-activating factor (PAF) is an important mediator and correlates with anaphylaxis severity. How well PAF correlates with severity relative to histamine or tryptase is not known. Expand
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Plasma cortisol levels in patients with septic shock.
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Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis.
BACKGROUND Platelet-activating factor (PAF) is an important mediator of anaphylaxis in animals, and interventions that block PAF prevent fatal anaphylaxis. The roles of PAF and PAF acetylhydrolase,Expand
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  • PDF
Detection of peanut allergens in breast milk of lactating women.
CONTEXT Most individuals who react to peanuts do so on their first known exposure. A potential but unproven route of occult exposure resulting in sensitization to peanut is via breast milk duringExpand
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