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Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer.
Twist is a basic helix loop helix protein that plays a role both in human development and in cancer biogenesis. While characterizing the effects of Twist on breast epithelial cell transformation, weExpand
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Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma
Hypoxia‐inducible factor‐1 (HIF‐1) is a transcription factor that plays an important role in tumor growth and metastasis by regulating energy metabolism and inducing angiogenesis to survive cellularExpand
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Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence ofExpand
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Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)
The hypoxia‐inducible factor 1 (HIF‐1) plays a critical role in cellular responses to hypoxia. The aim of the present study was to evaluate which genes are induced by hypoxia, and whether thisExpand
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The origin of vimentin expression in invasive breast cancer: epithelial–mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation
Vimentin expression is a rather rare finding in invasive breast cancer, and is associated with high tumour invasiveness and chemoresistance. It is currently explained by two different biologicalExpand
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Micrometastases or isolated tumor cells and the outcome of breast cancer.
BACKGROUND The association of isolated tumor cells and micrometastases in regional lymph nodes with the clinical outcome of breast cancer is unclear. METHODS We identified all patients in TheExpand
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Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.
BACKGROUND Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates gene expression in critical pathways involved in tumor growth and metastases. In this report, we investigatedExpand
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Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage*
Notch signaling is controlled by ligand binding, which unfolds a negative control region to induce proteolytic cleavage of the receptor. First, a membrane-proximal cleavage is executed by aExpand
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Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
PURPOSE Variable uptake of the glucose analog (18)fluorodeoxyglucose (FDG) has been noticed in positron emission tomography (PET) studies of breast cancer patients, with low uptake occurringExpand
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Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer.
Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72Expand
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