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Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.
PURPOSE The goal of this study was to investigate the role of Rho kinase in the modulation of aqueous humor outflow facility. Rho kinase, a critical downstream effector of Rho GTPase is recognized toExpand
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
Elevated intraocular pressure arising from impaired aqueous humor drainage through the trabecular pathway is a major risk factor for glaucoma. To understand the molecular basis for RhoExpand
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  • Open Access
Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.
Cellular contraction and relaxation and integrity of the actin cytoskeleton in trabecular meshwork (TM) tissue have been thought to influence aqueous humour outflow. However, the cellular pathwaysExpand
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Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide.Expand
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Effects of cholesterol-lowering statins on the aqueous humor outflow pathway.
PURPOSE To investigate the effects of cholesterol-lowering statin drugs on trabecular meshwork cellular properties and aqueous humor outflow. METHODS Primary cell cultures of porcine trabecularExpand
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  • Open Access
Influence of actin cytoskeletal integrity on matrix metalloproteinase-2 activation in cultured human trabecular meshwork cells.
PURPOSE The goal of this study was to investigate the possible link between actin cytoskeletal integrity and the activation of matrix metalloproteinases (MMPs) in trabecular meshwork (TM) cells. Expand
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  • Open Access
Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase.
zeta-Crystallin is a major protein in the lens of certain mammals. In guinea pigs it comprises 10% of the total lens protein, and it has been shown that a mutation in the zeta-crystallin gene isExpand
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Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.
PURPOSE Based on pharmacological inhibition of activity, a role has been proposed for Rho-kinase in the modulation of aqueous outflow and intraocular pressure (IOP). This study employed a molecularExpand
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  • Open Access
Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma
Abstract Purpose: Rho-associated protein kinase (ROCK) inhibitors lower intraocular pressure (IOP) by increasing aqueous outflow through the trabecular meshwork (TM). The preclinical characterizationExpand
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Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
Morphogenesis and shape of the ocular lens depend on epithelial cell elongation and differentiation into fiber cells, followed by the symmetric and compact organization of fiber cells within anExpand
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