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Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis (ACUTE–JIA): a multicentre randomised open-label clinical trial
Objectives In juvenile idiopathic arthritis (JIA), the efficacy of very early disease-modifying drug therapy, synthetic or biological, is not well known. Three alternative strategies were compared… Expand
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.
- P. Kulmala, K. Savola, +6 authors M. Knip
- The Journal of clinical investigation
- 15 January 1998
An unselected population of 755 siblings of children with insulin-dependent diabetes mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies (ICA), antibodies… Expand
Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group.
- E. Sabbah, K. Savola, +5 authors M. Knip
- The Journal of clinical endocrinology and…
- 1 May 1999
We analyzed 747 children, younger than 15 yr of age, with newly diagnosed diabetes, for antibodies to glutamic acid decarboxylase (GADA), the IA-2 protein (IA-2A), insulin (IAA), and islet cells, to… Expand
A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group.
Coxsackievirus B infections have been associated with clinical manifestation of insulin-dependent diabetes mellitus (IDDM) in several studies, but their initiating role in the slowly progressing… Expand
Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes.
OBJECTIVE To assess whether there are any differences in genetic, autoimmune, or clinical features between type 1 diabetes presenting in childhood and that diagnosed later. RESEARCH DESIGN AND… Expand
Faecal microbiome in new-onset juvenile idiopathic arthritis
- M. Tejesvi, M. Arvonen, +4 authors P. Vähäsalo
- Biology, Medicine
- European Journal of Clinical Microbiology…
- 1 March 2016
Alterations in the intestinal microbial flora have been linked with autoimmune diseases. Our objective was to analyse the composition of the faecal microbiome of children with new-onset juvenile… Expand
Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in children
- K. Savola, E. Sabbah, P. Kulmala, P. Vähäsalo, J. Ilonen, M. Knip
- Biology, Medicine
- 1 October 1998
Summary To study the persistence of Type I (insulin-dependent) diabetes mellitus associated autoantibodies and their relation to genetic risk markers and clinical characteristics of the disease after… Expand
Enterovirus infections are associated with the induction of β‐cell autoimmunity in a prospective birth cohort study
Enterovirus infections have been associated with the manifestation of clinical type 1 diabetes in a number of reports, and recent prospective studies have suggested that enterovirus infections may… Expand
Drug survival of the first and second course of anti-tumour necrosis factor agents in juvenile idiopathic arthritis
Objectives: To evaluate drug survival (continuation rates on drug) of anti-tumour necrosis factor (TNF) agents in juvenile idiopathic arthritis (JIA) and predictors for treatment discontinuation.… Expand
Infliximab or etanercept in the treatment of children with refractory juvenile idiopathic arthritis: an open label study
Objective: To study infliximab and etanercept in the treatment of refractory juvenile idiopathic arthritis (JIA). Methods: In a non-randomised, prospective, open label study, 24 patients (mean age… Expand