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Protein glycation, diabetes, and aging.
Biological amines react with reducing sugars to form a complex family of rearranged and dehydrated covalent adducts that are often yellow-brown and/or fluorescent and include many cross-linkedExpand
Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.
Age-associated increases in collagen cross-linking and accumulation of advanced glycosylation products are both accelerated by diabetes, suggesting that glucose-derived cross-link formation mayExpand
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.
Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purifiedExpand
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat
Abstract Subcutaneous (s.c.) injection of formalin induces a rapid and prolonged hyperalgesia across widespread areas of the body. This hyperalgesic state involves a brain‐to‐spinal cord pathway,Expand
Breakers of advanced glycation end products restore large artery properties in experimental diabetes.
Glucose and other reducing sugars react with proteins by a nonenzymatic, posttranslational modification process called nonenzymatic glycation. The formation of advanced glycation end products (AGEs)Expand
An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness.
  • M. Asif, J. Egan, +10 authors T. Regan
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 14 March 2000
Decreased elasticity of the cardiovascular system is one of the hallmarks of the normal aging process of mammals. A potential explanation for this decreased elasticity is that glucose can reactExpand
Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.
Proteins exposed to glucose over long periods are known to undergo physicochemical changes including crosslinking and formation of brown fluorescent pigments of poorly characterized structure. AcidExpand
A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.
Nonenzymatic glycosylation and cross-linking of proteins by glucose contributes to an age-associated increase in vascular and myocardial stiffness. Some recently sythesized thiazolium compoundsExpand
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone
An overproduction of proinflammatory cytokines by activated macrophages/monocytes mediates the injurious sequelae of inflammation, septic shock, tissue injury, and cachexia. We recently synthesized aExpand
Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage-deactivating agent.
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are characterized by episodic neurologic dysfunction, perivascular mononuclear cell inflammationExpand