Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
The findings uncover a novel mechanism which controls the mitochondrial fusion–fission machinery in vertebrates, and as MIEF1 is vertebrate‐specific, these data also reveal important differences between yeast and vertebrates in the regulation of mitochondrial dynamics.
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
- K. Gaengel, C. Niaudet, C. Betsholtz
- BiologyDevelopmental Cell
- 11 September 2012
Ouabain, a steroid hormone that signals with slow calcium oscillations
- O. Aizman, P. Uhlén, M. Lal, H. Brismar, A. Aperia
- BiologyProceedings of the National Academy of Sciences…
- 30 October 2001
It is shown in renal epithelial cells that ouabain, in doses causing only partial Na,K-ATPase inhibition, acts as a biological inducer of regular, low-frequency intracellular calcium ([Ca2+]i) oscillations that elicit activation of the transcription factor, NF-κB.
Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons
- O. Aizman, H. Brismar, A. Aperia
- BiologyNature Neuroscience
- 1 March 2000
Confocal microscopy is used to demonstrate that virtually all striatal neurons, both in vitro and in vivo, contained dopamine receptors of both D1 and D2 classes of receptors, and functional evidence for such colocalization is provided.
Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations*
- Ayako Miyakawa-Naito, P. Uhlén, A. Aperia
- BiologyJournal of Biological Chemistry
- 12 December 2003
It is reported that Na,K-ATPase and inositol 1,4,5-trisphosphate ( InsP3) receptor (InsP3R) form a cell signaling microdomain that, in the presence of ouabain, generates slow Ca2+ oscillations in renal cells.
Frequency decoding of calcium oscillations.
- E. Smedler, P. Uhlén
- BiologyBiochimica et Biophysica Acta
- 1 March 2014
Distinct Role of the N-terminal Tail of the Na,K-ATPase Catalytic Subunit as a Signal Transducer*
- Songbai Zhang, S. Malmersjö, A. Aperia
- BiologyJournal of Biological Chemistry
- 4 August 2006
A well conserved Na,K-ATPase motif is identified that binds to the inositol 1,4,5-trisphosphate receptor and can trigger an anti-apoptotic calcium signal.
Biochemistry of calcium oscillations.
- P. Uhlén, Nicolas Fritz
- BiologyBiochemical and Biophysical Research…
- 21 May 2010
Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells.
- P. Uhlén, Å. Laestadius, A. Richter‐Dahlfors
- Biology, MedicineNature
- 2000
It is shown that infection by uropathogenic Escherichia coli induces a constant, low-frequency oscillatory [Ca2+]i response in target primary rat renal epithelial cells induced by the secreted RTX (repeats-in-toxin) toxin alpha-haemolysin.
Spectral Analysis of Calcium Oscillations
- P. Uhlén
- BiologyScience's STKE
- 9 November 2004
This protocol presents a method for performing spectral analysis of Ca2+ oscillations using MATLAB software, which is crucial for understanding the general concept ofCa2+ signaling.
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