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Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
Mitochondrial morphology is controlled by two opposing processes: fusion and fission. Drp1 (dynamin‐related protein 1) and hFis1 are two key players of mitochondrial fission, but how Drp1 isExpand
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Ouabain, a steroid hormone that signals with slow calcium oscillations
The plant-derived steroid, digoxin, a specific inhibitor of Na,K-ATPase, has been used for centuries in the treatment of heart disease. Recent studies demonstrate the presence of a digoxin analog,Expand
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Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons
Despite the importance of dopamine signaling, it remains unknown if the two major subclasses of dopamine receptors exist on the same or distinct populations of neurons. Here we used confocalExpand
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The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
Angiogenesis, the process by which new blood vessels arise from preexisting ones, is critical for embryonic development and is an integral part of many disease processes. Recent studies have providedExpand
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Cell Signaling Microdomain with Na,K-ATPase and Inositol 1,4,5-Trisphosphate Receptor Generates Calcium Oscillations*
Recent studies indicate novel roles for the ubiquitous ion pump, Na,K-ATPase, in addition to its function as a key regulator of intracellular sodium and potassium concentration. We have previouslyExpand
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Frequency decoding of calcium oscillations.
BACKGROUND Calcium (Ca(2+)) oscillations are ubiquitous signals present in all cells that provide efficient means to transmit intracellular biological information. Either spontaneously or uponExpand
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Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells.
Pyelonephritis is one of the most common febrile diseases in children. If not treated appropriately, it causes irreversible renal damage and accounts for a large proportion of end stage renalExpand
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Distinct Role of the N-terminal Tail of the Na,K-ATPase Catalytic Subunit as a Signal Transducer*
Mounting evidence suggests that the ion pump, Na,K-ATPase, can, in the presence of ouabain, act as a signal transducer. A prominent binding motif linking the Na,K-ATPase to intracellular signalingExpand
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MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division
The role of MYC proteins in somatic stem and progenitor cells during development is poorly understood. We have taken advantage of a chick in vivo model to examine their role in progenitor cells ofExpand
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α-Haemolysin of uropathogenic E. coli induces Ca 2+ oscillations in renal epithelial cells
Pyelonephritis is one of the most common febrile diseases in children. If not treated appropriately, it causes irreversible renal damage and accounts for a large proportion of end stage renalExpand
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