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Influence of mitochondrial content on the sensitivity of respiratory control.
TLDR
Changes in oxidative capacity directly influence the sensitivity of cytosolic respiratory control and this, in turn, has important consequences for maintenance of cellular energy balance. Expand
Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies
TLDR
Strenuous ex vivo conditions were necessary to reveal that MM-CK absence in single and double mutants leads to a partial loss of tetanic force output, suggesting that there is a compensatory resiliency of loss-of-function and redirection of flux distributions in the metabolic network for cellular energy in the authors' mutants. Expand
Adenine nucleotide degradation in slow-twitch red muscle.
TLDR
The present results indicate that AdN metabolism in the soleus muscle is complex, yielding expected degradation products or a loss of total purines, depending on contraction conditions. Expand
Acute hypertrophic response of skeletal muscle to removal of synergists.
TLDR
The data indicate that surgical trauma is the causative factor of the inflammatory response in this hypertrophy model. Expand
Adenine nucleotide synthesis in exercising and endurance-trained skeletal muscle.
TLDR
Strenuous exercise leads to increased efflux of purine nucleoside and base that should necessitate recovery of adenine nucleotides by either the de novo synthesis or salvage pathway, but the response in synthesis rates due to exercise was similar with or without ribose supplementation. Expand
IMP metabolism in human skeletal muscle after exhaustive exercise.
TLDR
This study addressed whether AMP deaminase (AMPD)myosin binding occurs with deamination during intense exercise in humans and the extent of purine loss from muscle during the initial minutes of recovery and the effect of exercise on regulation of muscle purine content. Expand
AMP deaminase binding in contracting rat skeletal muscle.
TLDR
The results are consistent with myosin binding having a role in AMP deaminase activation and subsequent IMP formation in contracting muscle, and extensive binding during contractions was also evident without cellular acidosis (iodoacetic acid-treated muscle). Expand
De novo synthesis of adenine nucleotides in different skeletal muscle fiber types.
TLDR
This study evaluated whether there are corresponding differences in the rates of de novo synthesis of adenine nucleotide among fiber type sections of skeletal muscle using an isolated perfused rat hindquarter preparation and showed that intracellular glycine is closely related to the direct precursor pool. Expand
Adenine nucleotide metabolism in contracting skeletal muscle.
TLDR
Evidence from some studies of AMP deaminase-deficient persons suggests that an intact purine nucleotide cycle is required for normal muscle function during intense exercise; the issue is clouded, however, by the occurrence of asymptomatic AMPDeaminase deficiency. Expand
Increased peak oxygen consumption of trained muscle requires increased electron flux capacity.
TLDR
The exercise-induced adaptation of an increased muscle mitochondrial content appears to be essential for trained muscle to exhibit its increased O2 flux capacity. Expand
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