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Mucosal immunity in liver autoimmunity: a comprehensive review.
Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study.
Levels of alkaline phosphatase and bilirubin can predict outcomes (liver transplantation or death) of patients with PBC and might be used as surrogate end points in therapy trials.
Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.
An international, multicenter meta-analysis of patients with PBC treated with ursodeoxycholic acid at liver centers in 8 European and North American countries developed and validated a risk score to predict transplantation-free survival and identified patients who would survive for 5 years and 10 years (responders) with positive predictive values.
Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study
It is demonstrated that 12-month biochemical non-response is associated with increased future risk of developing HCC in PBC, and such risk stratification is relevant to patient care and development of new therapies.
The gut-adherent microbiota of PSC–IBD is distinct to that of IBD
It is demonstrated that the Veillonella genus showed a marked increase in PSC–IBD, in comparison with both healthy controls and patients with UC alone, and there remains a challenging task to link dysbiosis with disease pathogenesis.
Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo
RXFP1 was identified as a potential new therapeutic target for PHT and MF activation status through a selective and significant reduction in portal pressure in pathologically distinct PHT models, through augmentation of intrahepatic NO signaling and a dramatic reduction in contractile filament expression in HSC‐MFs.
Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis.
Inflammatory CD28(-) T cells accumulate in livers of patients with PSC and localize around bile ducts; these effects are reversed by vitamin D in vitro.
Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis.
In an analysis of data from individual patients with PSC worldwide, significant variation in clinical course associated with age at diagnosis, sex, and ductal and IBD subtypes is found.
Obeticholic acid for the treatment of primary biliary cirrhosis
- P. Trivedi, G. Hirschfield, M. Gershwin
- Medicine, BiologyExpert review of clinical pharmacology
- 2 January 2016
Data from recent Phase II and III controlled trials suggest a therapeutic impact of OCA in PBC biochemical nonresponders, as evidenced by change in proven laboratory surrogates of long-term outcome.