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Targeted therapy for uveal melanoma.
Fine-needle aspiration biopsy of uveal melanoma: outcomes and complications
TLDR
FNAB for uveal melanoma with 25-gauge needle is a safe procedure that can yield diagnostic and prognostic information in vast majority of cases (92% and 85%, respectively), even so, only about half of the eligible cases eventually enrolled into the adjuvant therapy trial.
Prevention of mammary tumors with a chimeric HER-2 B-cell epitope peptide vaccine.
TLDR
The engineered, chimeric peptide B-cell immunogen MVF-HER-2(628-647) may have applications in the prevention of HER-2-overexpressing cancers.
Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells
TLDR
The ability of the modified Ad vector to infect CD40-positive dendritic cells and tumor cells with a high efficiency makes this virus a prototype of choice for the derivation of therapeutic vectors for the genetic immunization and targeted destruction of tumors.
The Role of the Immune Response in Merkel Cell Carcinoma
TLDR
It is suggested that immune modulation, including reduction of immune suppression, can result in tumor regression and better understanding on how MCPyV and MCC evade the immune response will be necessary to develop effective immunotherapies.
Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer
Dendritic cells (DCs) are potent initiators of immune responses, and the infiltration of DCs into tumors may confer an improved prognosis. Whether the injection of DCs directly into tumors can
Enhanced transduction of mouse bone marrow-derived dendritic cells by repetitive infection with self-complementary adeno-associated virus 6 combined with immunostimulatory ligands
TLDR
It is reported here that efficient transduction of mouse bone marrow-derived DC can be achieved with self-complementary (sc) rAAV encapsidated in serotype 6 capsid, demonstrating the potential utility of sc AAV6-transduced vectors inTransduction of DC for genetic vaccination approaches.
Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma
TLDR
A role for epigenetic mechanisms in the development of metastasis in patients with uveal melanoma and the analysis of miRs as biomarkers of metastatic risk is supported, suggesting that potentially useful blood miRs may be derived from the host response as well as the tumor.
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
TLDR
A previously unappreciated role for TMB as a determinant of immune-mediated survival of breast cancer patients is demonstrated and candidate immune-regulatory mechanisms associated with immunologically cold tumors are identified.
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