• Publications
  • Influence
Protein C deficiency in a controlled series of unselected outpatients: an infrequent but clear risk factor for venous thrombosis (Leiden Thrombophilia Study)
A deficiency of protein C (PC), antithrombin, or protein S is strongly associated with deep-vein thrombosis in selected patients and their families. However, the strength of the association withExpand
  • 348
  • 6
  • PDF
The specificity of the CDT assay in general practice: the influence of common chronic diseases and medication on the serum CDT concentration.
Early recognition of alcohol problems by general practitioners might be enhanced by the use of better alcohol markers. Several studies have revealed promising results for the carbohydrate-deficientExpand
  • 47
  • 3
Screening for metabolic vitamin B12 deficiency by holotranscobalamin in patients suspected of vitamin B12 deficiency: a multicentre study
Background Vitamin B12 deficiency occurs frequently, especially among the elderly. However, screening for vitamin B12 deficiency is hampered by poor sensitivity of the existing total vitamin B12Expand
  • 61
  • 3
The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants
Heart failure has been identified as a risk factor for increased coumarin anticoagulant responsiveness in several small‐scale experiments. Epidemiological studies quantifying the risk ofExpand
  • 56
  • 3
  • PDF
No clear effect of diabetes education on glycaemic control for Turkish type 2 diabetes patients: a controlled experiment in general practice.
BACKGROUND In Turkish immigrant diabetics, problems with communication and cultural differences may hinder delivery of diabetes care. METHODS In a prospective controlled study, the effect of anExpand
  • 24
  • 3
Screening for deep vein thrombosis and pulmonary embolism in outpatients with suspected DVT or PE by the sequential use of clinical score: a sensitive quantitative D-dimer test and noninvasive
The requirement for a safe diagnostic strategy should be based on an overall posttest incidence of venous thromboembolism (VTE) of less than 1% during 3-month follow-up. The negative predictive valueExpand
  • 24
  • 2
The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon.
The principal enzyme involved in coumarin metabolism is CYP2C9. Allelic variants of CYP2C9, CYP2C9*2 and CYP2C9*3, code for enzymes with reduced activity. Despite increasing evidence that patientsExpand
  • 89
  • 1
Comparing the diagnostic accuracy of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean cell volume in a general practice population.
In certain populations, the biological alcohol marker carbohydrate-deficient transferrin (CDT) is known to have a high diagnostic accuracy. The aim of this study was to compare the diagnosticExpand
  • 67
  • 1
Variant expression of lactate dehydrogenase complexes, interfering with isoenzyme analysis.
Three patients with an elevated serum LD activity and unusual, but quite different LD isoenzyme patterns, were studied. It was shown by immunofixation procedures, that complexes between LD isoenzymesExpand
  • 6
  • 1
Evidence for Safe Exclusion of Deep Vein Thrombosis (DVT) by a Rapid ELISA D-Dimeer Test at Cut-Off Levels of 500 and 1000 Ng/Ml in 1046 Consecutive Outpatients with Suspected DVT.
Introduction.A normal compression ultrasonography (CUS) safely excludes proximal deep vein thrombosis (DVT) with a negative predictive value of 97% indicating the need to repeat CUS testing withinExpand
  • 1
  • 1