Adipokines: inflammation and the pleiotropic role of white adipose tissue
It is suggested that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue.
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells, indicates that glucose delivery into cells is a process of considerable complexity.
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
The key challenges in establishing the secretory functions of white fat are to identify the complement of secreted proteins, to establish the role of each secreted protein, and to assess the pathophysiological consequences of changes in adipocyte protein production with alterations in adiposity.
Signalling role of adipose tissue: adipokines and inflammation in obesity.
The elevated production of inflammation-related adipokines is increasingly considered to be important in the development of diseases linked to obesity, particularly Type II diabetes and the metabolic syndrome.
Endocrine and signalling role of adipose tissue: new perspectives on fat.
- P. Trayhurn
- BiologyActa Physiologica Scandinavica
- 1 August 2005
From the wide range of adipokines now identified, it is evident that WAT is highly integrated into overall physiological regulation, involving extensive crosstalk with other organs and multiple metabolic systems.
Hypoxia and adipose tissue function and dysfunction in obesity.
- P. Trayhurn
- BiologyPhysiological Reviews
Overall, hypoxia has pervasive effects on the function of adipocytes and appears to be a key factor in adipose tissue dysfunction in obesity.
Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy
- L. Hardie, P. Trayhurn, D. Abramovich, P. Fowler
- Psychology, BiologyClinical Endocrinology
- 1 July 1997
To investigate whether leptin is linked to reproduction, circulating levels were measured longitudinally throughout spontaneous menstrual cycles and during pregnancy in normal women.
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
- Bohan Wang, I. S. Wood, P. Trayhurn
- BiologyPflügers Archiv: European Journal of Physiology
- 3 July 2007
It is demonstrated that hypoxia induces extensive changes in human adipocytes in the expression and release of inflammation-related adipokines, leading to obesity-associated diseases.
Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus
Dual in situ hybridization studies for leptin receptor and NPY gene expression in the mouse arcuate nucleus are reported, providing the first direct evidence that leptin acts on cells that express NPY mRNA.