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Cyanobacterial cytotoxicity versus toxicity to brine shrimp Artemia salina.
Cytotoxicity and secondary metabolites production in terrestrial Nostoc strains, originating from different climatic/geographic regions and habitats: Is their cytotoxicity environmentally dependent?
The overall occurrence of cytotoxicity was found to be 33%, which corresponds with previously published data, but the frequency differs significantly among strains, which originate from different climatic regions and microsites (particular localities).
Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity
A new fluorescence assay for measuring IDO1 activity suitable for high-throughput screening of compound libraries for novelIDO1 inhibitors, and has a lower limit of detection, equating to 153 nM N-formylkynurenine, which is over 30-fold lower than the limits of detection of existing assays for IDO 1 activity.
Cytotoxic Lipopeptide Muscotoxin A, Isolated from Soil Cyanobacterium Desmonostoc muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity.
The isolated new cyclic undecalipopeptides muscotoxin A and B containing unique lipophilicresidue 3-amino-2,5-dihydroxydecanoic acid (5-OH Ahdoa) strengthen the evidence that cyanobacterial lipopeptide specifically disrupt mammalian cell membranes and bring new insights into the mechanism of this effect.
Tooling concepts for FMS
New tool flow strategy based on random machining in FMS, where common tool pool is used and automatic tool transport matches transport of parts is described.
Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening
New scaffolds able to inhibit both IDO1 and TDO2 are identified, thus enriching the collection of dual IDO 1/TDO2 inhibitors and providing chemical matter for potential development into future anticancer drugs.
Biosynthesis of Colabomycin E, a New Manumycin‐Family Metabolite, Involves an Unusual Chain‐Length Factor
Biological activity assays indicated that colabomycin E significantly inhibited IL‐1β release from THP‐1 cells and might thus potentially act as an anti‐inflammatory agent.