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Effects of iodinated contrast media on pulmonary airway resistance in anesthetized guinea pigs.
TLDR
An in vivo study in guinea pigs found no apparent relationship between the size of the increase in airway resistance and the charge or molecular weight of the contrast agent molecule or the pharmaceutical formulation.
[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
TLDR
The No Observed Adverse Effect Level (NOAEL) for general toxicity of dams and embryo-fetal development was 0.3 mmol/kg/day, and that of mated NZW female rabbits treated with Gadobenate dimeglumine (E7155) caused initial, notable loss of body weight and reduction in food consumption.
Pharmacokinetics and tissue distribution in animals of gadobenate ion, the magnetic resonance imaging contrast enhancing component of gadobenate dimeglumine 0.5 M solution for injection (MultiHance).
TLDR
Gadobenate dimeglumine combines the properties of an extracellular-fluid agent with those of a hepatobiliary agent and its complete elimination and biological stability satisfy the requirements for its safe use in humans.
Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium.
TLDR
Based on the wide margins of safety demonstrated in different species, particularly in primates, gadobenate dimeglumine can be considered as safe in the range of clinical doses recommended for magnetic resonance imaging.
The haemodynamic effects of iodinated water soluble radiographic contrast media: a review.
TLDR
The pathophysiology of the haemodynamic effects of RCM is discussed and some insight is offered into the biology of the endothelium and vascular smooth muscle cells as well as the pharmacology of the important vasoactive mediators endothelin and adenosine are offered.
Serious or fatal complications after inadvertent administration of ionic water-soluble contrast media in myelography.
TLDR
The serious or fatal reactions observed are a tragic confirmation of the predictive power of neurotoxicity data obtained in animal studies with various iodinated water-soluble compounds.
Pharmacokinetics and tissue distribution of iomeprol in animals.
TLDR
The pharmacokinetics of iomeprol, a new triiodinated nonionic radiographic Contrast agent, has been studied in rats, rabbits and dogs and the overall profile was very similar to the published profiles of other radiographic contrast agents used in uroangiography.
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
TLDR
Neurotoxicity of monomer or dimer contrast media depends more on chemical structure characteristics other than hydrophilicity than on the physicochemical characteristics of their solutions.
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