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Functional reconstruction and synthetic mimicry of a conformational epitope using CLIPS™ technology
This paper describes immunization studies with CLIPS‐constrained peptides covering only the major part (β3‐loop) of a structurally complex antigenic site on human Follicle Stimulating HormoneExpand
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The Discretionary Use of Electronic Media
Communicating negative information to subordinates is one of the more discomforting managerial responsibilities. Yet managers frequently have to make tough decisions which sometimes result inExpand
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Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.
CD20 is a cell-surface marker of normal and malignant B cells. Rituximab, a monoclonal antibody targeting CD20, has improved the treatment of malignant lymphomas. Therapeutic CD20 antibodies areExpand
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Rapid and Quantitative Cyclization of Multiple Peptide Loops onto Synthetic Scaffolds for Structural Mimicry of Protein Surfaces
Structure-based design of synthetic peptide-based molecules that mimic the functional site of natural proteins, plays an important role in drug discovery nowadays. Their application is widespread,Expand
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Affinity maturation of antibodies assisted by in silico modeling
Rational engineering methods can be applied with reasonable success to optimize physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a combined CDR3 walkingExpand
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Islam and the environment
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Complete asymmetric induction of supramolecular chirality in a hydrogen-bonded assembly
Chirality at the supramolecular level involves the non-symmetric arrangement of molecular components in a non-covalent assembly,. Supramolecular chirality is abundant in biology, for example in theExpand
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Megahydropolis: Coastal cities in the context of global environmental change
Abstract Coastal cities are critical areas for global environmental change, but they have not been a focus of study in coastal zone management or urban planning. This paper lays the conceptualExpand
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