Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells.
- P. Thomas, Y. Pang, E. Filardo, J. Dong
- BiologyEndocrinology
- 1 February 2005
GPR30, an orphan receptor unrelated to nuclear estrogen receptors, has all the binding and signaling characteristics of a mER, and the identification of a second distinct class of GPCR-like steroid membrane receptors suggests a widespread role for GPCRs in nonclassical steroid hormone actions.
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
- Yong Zhu, C. Rice, Y. Pang, M. Pace, P. Thomas
- BiologyProceedings of the National Academy of Sciences…
- 6 February 2003
Cloning of a cDNA from spotted seatrout ovaries encoding a protein that satisfies the following seven criteria for its designation as a steroid membrane receptor suggests the fish protein is a membrane progestin receptor mediating a “nonclassical” action of progestins to induce oocyte maturation in fish.
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
The identification, cloning, and characteristics of other members of this hitherto unknown family of putative mPRs from several vertebrate species, including human, mouse, pig, Xenopus, zebrafish, and Fugu, with highly conserved nucleotide and deduced amino acid sequences and similar structures to the spotted seatrout mPR are reported.
Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts.
- M. Hawkins, J. W. Thornton, D. Crews, J. Skipper, A. Dotte, P. Thomas
- BiologyProceedings of the National Academy of Sciences…
- 26 September 2000
This paper describes three distinct estrogen receptor (ER) subtypes: ERalpha, ERbeta, and a unique type, ERgamma, cloned from a teleost fish, the Atlantic croaker Micropogonias undulatus; the first…
GPR30: a seven-transmembrane-spanning estrogen receptor that triggers EGF release
- E. Filardo, P. Thomas
- BiologyTrends in endocrinology and metabolism
- 1 October 2005
Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.
- E. Filardo, J. Quinn, P. Thomas
- Biology, ChemistryEndocrinology
- 1 July 2007
It is shown that detectable expression of GPR30 on the surface of transfected HEK-293 cells can be selected by fluorescence-activated cell sorting, and results suggest that G PR30, like other 7TMRs, functions as a plasma membrane receptor.
Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology.
- E. Filardo, P. Thomas
- BiologyEndocrinology
- 11 April 2012
The role of GPER-1 in female reproductive cancers as well as renal and vascular physiology is discussed and the formal renaming of this receptor to its current functional designate, G protein-coupled estrogen receptor (ER) (GPER)-1 is discussed.
Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term.
- E. Karteris, S. Zervou, P. Thomas
- BiologyMolecular Endocrinology
- 1 July 2006
The presence of two novel functional membrane progestin receptors (mPRs), mPRalpha and mPRbeta, in human myometrium that are differentially modulated during labor and by steroids in vitro are reported.
Widespread endocrine disruption and reproductive impairment in an estuarine fish population exposed to seasonal hypoxia
- P. Thomas, M. Rahman, I. Khan, J. A. Kummer
- BiologyProceedings of the Royal Society B: Biological…
- 7 November 2007
It is shown that chronic environmental exposure of Atlantic croaker to hypoxia in a Florida estuary caused marked suppression of ovarian and testicular growth which was accompanied by endocrine disruption, indicating that the stimulatory serotonergic neuroendocrine pathway is a major site of Hypoxia-induced inhibition.
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