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Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amyloid beta-peptides (Abeta), which derive from the proteolitic cleavage of the amyloid precursorExpand
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Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2‐T1R3 receptor
  • P. Temussi
  • Medicine, Chemistry
  • FEBS letters
  • 28 August 2002
Sweet tasting proteins interact with the same receptor that binds small molecular weight sweeteners, the T1R2–T1R3 G‐protein coupled receptor, but the key groups on the protein surface responsibleExpand
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Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.
Nociceptin (NC) and some of its fragments as well as nociceptin-(1-13)-peptide amide [NC- (1-13)-NH2] and a series of its analogues were prepared and tested in the mouse vas deferens in an attempt toExpand
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From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor.
The sweet taste receptor, a heterodimeric G protein coupled receptor (GPCR) protein, formed by the T1R2 and T1R3 subunits, recognizes several sweet compounds including carbohydrates, amino acids,Expand
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The good taste of peptides.
  • P. Temussi
  • Chemistry, Medicine
  • Journal of peptide science : an official…
  • 1 February 2012
The taste of peptides is seldom one of the most relevant issues when one considers the many important biological functions of this class of molecules. However, peptides generally do have a taste,Expand
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From Alzheimer to Huntington: why is a structural understanding so difficult?
An increasing family of neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases, prion encephalopathies and cystic fibrosis is associated with aggregation of misfoldedExpand
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Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps.
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMRExpand
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Unbiased cold denaturation: low- and high-temperature unfolding of yeast frataxin under physiological conditions.
Since the cold denaturation of most proteins occurs well below 0 °C, full access to the cold denatured state is normally limited by water freezing. To circumvent this difficulty the temperature ofExpand
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The alpha-to-beta conformational transition of Alzheimer's Abeta-(1-42) peptide in aqueous media is reversible: a step by step conformational analysis suggests the location of beta conformation
Current views of the role of beta-amyloid (Abeta) peptide fibrils range from regarding them as the cause of Alzheimer's pathology to having a protective function. In the last few years, it has alsoExpand
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