• Publications
  • Influence
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
TLDR
It is demonstrated that EAA stimulate MPS independently of increased insulin availability, and in the elderly, a deficit in MPS in the basal state is unlikely; and the decreased sensitivity and responsiveness of MPS to EAA, associated with decrements in the expression and activation of components of anabolic signaling pathways, are probably major contributors to the failure of muscle maintenance inThe elderly.
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
TLDR
It is shown that the intracellular supply of large neutral amino acids in T cells was regulated by pathogens and the T cell antigen receptor (TCR), and that Slc7a5-null T cells were unable to metabolically reprogram in response to antigen and did not undergo clonal expansion or effector differentiation.
Amino acid transporters: roles in amino acid sensing and signalling in animal cells.
TLDR
Evidence supporting the idea that distinct amino acid "receptors" function to detect and transmit certain nutrient stimuli in higher eukaryotes is reviewed, and the role that amino acid transporters may play in the sensing of amino acid levels is focused on.
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.
TLDR
It is shown that inhibition of protein synthesis by any of several protein synthesis inhibitors tested allows insulin to regulate 4E-BP1 or S6K1 in amino-acid-deprived cells, as does the addition of amino acids to the medium.
Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.
TLDR
It is hypothesize (by extrapolation from knowledge of the yeast Ssy1 transceptor) that, at least for SNAT2, the transceptor discriminates between extracellular and intracellular amino acid stimuli when evoking a signal.
A Novel Zinc-regulated Human Zinc Transporter, hZTL1, Is Localized to the Enterocyte Apical Membrane*
TLDR
The localization, regulatory properties, and function of hZTL1 indicate a role in regulating the absorption of dietary zinc across the apical enterocyte membrane.
Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation
TLDR
It is shown that the intracellular supply of large neutral amino acids (LNAAs) in T cells is regulated by pathogen and the T cell antigen receptor (TCR), and that pathogen control of System L transporters is a critical metabolic checkpoint for T cells.
Role of amino acid transporters in amino acid sensing.
  • P. Taylor
  • Biology
    The American journal of clinical nutrition
  • 2014
TLDR
This review considers recent advances in understanding of the AA-sensing functions of AA transporters in both epithelial and nonepithelial cells, and considers dual receptor-transporter functions, operating as "transceptors" to sense extracellular AA availability upstream of intracellular signaling pathways.
H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.
TLDR
The identification in intact epithelia of a cooperative functional relationship between PAT1 (H(+ /amino acid symport) and NHE3 (N(+) /H(+) exchange) explains the apparent Na + dependence of the imino acid carrier in studies with mammalian intestine.
...
...