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High‐fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. We hypothesized that mice exposed to a similar dietExpand
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The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) preventsExpand
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Noncanonical Autophagy Promotes the Visual Cycle
Ji-Young Kim,1,5 Hui Zhao,1,5 Jennifer Martinez,2 Teresa Ann Doggett,1 Alexander V. Kolesnikov,1 Peter H. Tang,3 Zsolt Ablonczy,3 Chi-Chao Chan,4 Zhenqing Zhou,1 Douglas R. Green,2,* and Thomas A.Expand
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Human retinal pigment epithelium cells as functional models for the RPE in vivo.
PURPOSE The two most commonly used in vitro models of the retinal pigment epithelium (RPE) are fetal human RPE (fhRPE) and ARPE-19 cells; however, studies of their barrier properties have producedExpand
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HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma.
BACKGROUND The percentage of reduced coenzyme Q(10) (CoQ(10)H(2)) in total coenzyme Q(10) (TQ(10)) is decreased in plasma of patients with prematurity, hyperlipidemia, and liver disease. CoQ(10)H(2)Expand
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Noncanonical Autophagy Promotes the Visual Cycle
Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk degradation of cellularExpand
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A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.
PURPOSE Polymorphisms in factor H (fH), an inhibitor of the alternative pathway (AP) of complement activation, are associated with increased risk for age-related macular degeneration (AMD). TheExpand
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Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection.
BACKGROUND Ubiquinone-responsive multiple respiratory chain dysfunction due to coenzyme Q(10) (CoQ(10)) deficiency has been previously identified in muscle biopsies. However, previous methods areExpand
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Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies.
Coenzyme Q10 content, pathology evaluation, and electron transport chain (ETC) enzyme analysis were determined in muscle biopsy specimens of 82 children with suspected mitochondrial myopathy. DataExpand
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Bioequivalence of coenzyme Q10 from over-the-counter supplements
Abstract The objective of this study was to compare the relative bioavailability of two new products with solubilized and non-solubilized over-the-counter (OTC) coenzyme Q 10 products. Nine healthyExpand
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