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Noncanonical Autophagy Promotes the Visual Cycle

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Human retinal pigment epithelium cells as functional models for the RPE in vivo.

TLDR
Property of fhRPE cells align with a functionally normal RPE in vivo, while ARPE-19 cells resemble a pathologic or aged RPE, suggesting a utility for both cell types in understanding distinct, particular aspects of RPE function.
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A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.

TLDR
In therapeutically relevant paradigms involving delayed treatment after injury, CR2-fH was effective in reducing CNV and provided approximately 60% of the amount of protection of that seen in factor B-deficient mice that lacked functional AP.
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Noncanonical Autophagy Promotes the Visual Cycle

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New insights into retinoid metabolism and cycling within the retina

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The Mammalian Cone Visual Cycle Promotes Rapid M/L-Cone Pigment Regeneration Independently of the Interphotoreceptor Retinoid-Binding Protein

TLDR
It is concluded that the retina visual cycle is critical for the initial rapid regeneration of mouse M/L-cone pigment during dark adaptation, whereas the slower RPEVisual cycle is required to complete the process.
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Atypical Leber Hereditary Optic Neuropathy: 18 Year Interval Between Eyes.

TLDR
This 18 year interval between eye involvement in LHON is the longest reported to date and reinforces the variability in presentation and progression seen in this disease.
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RPE65 Is Present in Human Green/Red Cones and Promotes Photopigment Regeneration in an In Vitro Cone Cell Model

TLDR
It is found that RPE65 was selectively expressed in human green/red cones but absent from blue cones and mediated ester hydrolysis for photopigment synthesis in vitro, suggesting that cone R PE65 supports human diurnal vision, potentially enhancing the authors' strategies for treating LCA2.
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Effective and sustained delivery of hydrophobic retinoids to photoreceptors.

TLDR
These experiments are the first to show a sustained delivery of retinoids in mice and suggest a strategy for potential clinical therapeutic development.
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The Influence of Universal Face Mask Use on Endophthalmitis Risk after Intravitreal Anti–Vascular Endothelial Growth Factor Injections

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