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Depletion of definitive gut endoderm in Sox17-null mutant mice.
These findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endODerm formation is likely to be conserved among vertebrates. Expand
SOX9 directly regulates the type-ll collagen gene
It is shown that SOX9 protein binds specifically to sequences in the first intron of human COL2A1, the gene encoding type-ll collagen, which implicate abnormal regulation of COL2a1 during chondrogenesis as a cause of the skeletal abnormalities associated with campomelic dysplasia. Expand
SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse.
It is shown that mouse SOX9 protein is able to bind to a SOX/SRY consensus motif in DNA and contains a modular transcriptional activation domain, consistent with a role forSOX9 as a transcription factor acting on genes involved in cartilage development. Expand
Proliferation and migration of primordial germ cells during compensatory growth in mouse embryos.
  • P. Tam, M. Snow
  • Biology, Medicine
  • Journal of embryology and experimental morphology
  • 1 August 1981
Primitive-streak-stage mouse embryos treated with Mitomycin C injected intraperitoneally into pregnant females showed impaired fertility and poor breeding performance, mainly caused by a severe reduction of the primordial germ cell population in early embryonic life. Expand
Gene function in mouse embryogenesis: get set for gastrulation
Recent discoveries about the lead up to gastrulation are discussed, including early manifestations of asymmetry, coordination of cell and tissue movements and the interactions of transcription factors and signalling activity for lineage allocation and germ-layer specification. Expand
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
The investigation into lineage allocation and early asymmetries in the pre- and peri-implantation mouse embryo is gaining momentum. As we review here, new insights have been gained into the cellularExpand
Mouse gastrulation: the formation of a mammalian body plan
The mouse embryo before and during gastrulation is explored, highlighting its similarities with other vertebrate embryos and its unique characteristics. Expand
Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation.
CDKL5 is confirmed as another locus associated with epilepsy and X-linked mental retardation and suggested that mutations in CDKL 5 can lead to a clinical phenotype that overlaps RTT, however, it remains to be determined whether CDkL5 mutations are more prevalent in specific clinical subgroups of RTT or in other clinical presentations. Expand
The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.
Mouse epiblast stem cells are derived from a series of EpiSC lines from pregastrula stage to late-bud-stage mouse embryos and it is found that the transcriptomes of these cells are hierarchically distinct from those of the embryonic stem cells, induced pluripotent stem cells (iPSCs), and epiblasts/ectoderm. Expand