Behavioral manifestations of autism in the first year of life
- L. Zwaigenbaum, S. Bryson, Tracey Rogers, W. Roberts, J. Brian, P. Szatmari
- PsychologyInternational Journal of Developmental…
- 1 April 2005
Structural variation of chromosomes in autism spectrum disorder.
- C. Marshall, A. Noor, S. Scherer
- BiologyAmerican Journal of Human Genetics
- 8 February 2008
Functional impact of global rare copy number variation in autism spectrum disorders
- D. Pinto, A. Pagnamenta, C. Betancur
- BiologyNature
- 15 July 2010
The genome-wide characteristics of rare (<1% frequency) copy number variation in ASD are analysed using dense genotyping arrays to reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
The Prevalence of Anxiety and Mood Problems among Children with Autism and Asperger Syndrome
- Joseph A. Kim, P. Szatmari, S. Bryson, D. Streiner, F. Wilson
- Psychology, Medicine
- 1 June 2000
Data indicate that high-functioning PDD children are at greater risk for mood and anxiety problems than the general population but the correlates and risk factors for these comorbid problems remain unclear.
Synaptic, transcriptional, and chromatin genes disrupted in autism
- S. De Rubeis, Xin He, J. Buxbaum
- BiologyNature
- 29 October 2014
Using exome sequencing, it is shown that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate of < 0.05, plus a set of 107 genes strongly enriched for those likely to affect risk (FDR < 0.30).
Early Language and Communication Development of Infants Later Diagnosed with Autism Spectrum Disorder
- S. Mitchell, J. Brian, S. Bryson
- PsychologyJournal of Developmental and Behavioral…
- 1 April 2006
It is confirmed that delays in communication and language development are apparent early in life in children with ASD, and developmental surveillance should include monitoring for delays in gesture, which may be among the earliest signs of ASD.
Ontario Child Health Study. II. Six-month prevalence of disorder and rates of service utilization.
The utilization data indicated that children with these psychiatric disorders, compared with children without these disorders, were almost four times more likely to have received mental health or social services in the six months preceding this study.
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism
- F. Satterstrom, J. Kosmicki, R. Walters
- Biology, PsychologyCell
- 30 November 2018
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
- P. Szatmari, A. Paterson, K. J. Meyer
- BiologyNature Genetics
- 1 March 2007
Linkage and copy number variation analyses implicate chromosome 11p12–p13 and neurexins, respectively, among other candidate loci, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
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