• Publications
  • Influence
Regulation of tumor pH and the role of carbonic anhydrase 9
The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused regions. Hypoxia activates a complex gene expression program, mediated by hypoxia inducible factor 1Expand
  • 438
  • 12
Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy
Purpose: Bevacizumab, an anti-VEGFA antibody, inhibits the developing vasculature of tumors, but resistance is common. Antiangiogenic therapy induces hypoxia and we observed increased expression ofExpand
  • 179
  • 12
Intracellular pH regulation in heart.
Intracellular pH (pHi) is an important modulator of cardiac excitation and contraction, and a potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane mechanismsExpand
  • 196
  • 11
S0859, an N‐cyanosulphonamide inhibitor of sodium‐bicarbonate cotransport in the heart
Intracellular pH (pHi) in heart is regulated by sarcolemmal H+‐equivalent transporters such as Na+‐H+ exchange (NHE) and Na+‐HCO3 − cotransport (NBC). Inhibition of NBC influences pHi and can beExpand
  • 70
  • 10
The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths*
We have studied the role of carbonic anhydrase 9 (CA9), a cancer-associated extracellular isoform of the enzyme carbonic anhydrase in multicellular spheroid growths (radius of ∼300 μm) of human colonExpand
  • 224
  • 8
The chemistry, physiology and pathology of pH in cancer
Cell survival is conditional on the maintenance of a favourable acid–base balance (pH). Owing to intensive respiratory CO2 and lactic acid production, cancer cells are exposed continuously to largeExpand
  • 191
  • 6
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
In this review, we discuss the role of the tumour-associated carbonic anhydrase isoform IX (CAIX) in the context of pH regulation. We summarise recent experimental findings on the effect of CAIX onExpand
  • 185
  • 5
Dual Role of CO2/HCO3− Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths*
Intracellular pH (pHi), a major modulator of cell function, is regulated by acid/base transport across membranes. Excess intracellular H+ ions (e.g. produced by respiration) are extruded byExpand
  • 68
  • 5
pH‐Regulated Na+ Influx into the Mammalian Ventricular Myocyte: The Relative Role of Na+‐H+ Exchange and Na+‐HCO3− Co‐Transport
In the heart, intracellular Na+ concentration (Na+i) is a controller of intracellular Ca2+ signaling, and hence of key aspects of cell contractility and rhythm. Na+i will be influenced by variationExpand
  • 44
  • 5
Modelling intracellular H(+) ion diffusion.
Intracellular pH, an important modulator of cell function, is regulated by plasmalemmal proteins that transport H(+), or its equivalent, into or out of the cell. The pH(i) is also stabilised byExpand
  • 59
  • 5