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Adenosine and brain function.
Publisher Summary This chapter describes the role of adenosine in brain function. Adenosine is an endogenous neuromodulator that influences many functions in the central nervous system (CNS). TheExpand
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DARPP-32: an integrator of neurotransmission.
Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified initially as a major target for dopamine and protein kinase A (PKA) in striatum. However, recent advances nowExpand
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Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum.
Many drugs of abuse exert their addictive effects by increasing extracellular dopamine in the nucleus accumbens, where they likely alter the plasticity of corticostriatal glutamatergic transmission.Expand
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Distribution, biochemistry and function of striatal adenosine A2A receptors
It is well known that the nucleoside adenosine exerts a modulatory influence in the central nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the subject of theExpand
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Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity
A complex chain of intracellular signaling events, critically important in motor control, is activated by the stimulation of D1-like dopamine (DA) receptors in striatal neurons. At corticostriatalExpand
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Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
DARPP-32 is a dual-function protein kinase/phosphatase inhibitor that is involved in striatal signaling. The phosphorylation of DARPP-32 at threonine 34 is essential for mediating the effects of bothExpand
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Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny neurons in the striatum of theExpand
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Diverse Psychotomimetics Act Through a Common Signaling Pathway
Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states inExpand
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Depression in Parkinson disease—epidemiology, mechanisms and management
Depression occurs in around 35% of patients with Parkinson disease (PD) and is often persistent. Symptoms of depression can be evident in individuals at the time of diagnosis and might develop in theExpand
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Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.
In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of theExpand
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