Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis.
Oral administration of a small molecule inhibitor of tryptophan hydroxylase-1 once daily for up to six weeks acts prophylactically or therapeutically, in a dose-dependent manner, to treat osteoporosis in ovariectomized rodents because of an isolated increase in bone formation.
New insights into the genetic basis of infertility
- T. Venkatesh, P. Suresh, R. Tsutsumi
- Biology, MedicineThe application of clinical genetics
- 1 December 2014
Information is provided from a systematic analysis of the literature related to current research into the genetics of infertility affecting both sexes regarding ovulation defects, spermatogenic failure, and infections.
YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling.
Emerging roles of MCPH1: expedition from primary microcephaly to cancer.
tRFs: miRNAs in disguise.
Factors associated with 2009 pandemic influenza A (H1N1) vaccination acceptance among university students from India during the post-pandemic phase
The study shows that the vaccination coverage among university students remains very low in the post-pandemic period and doubts about the safety and effectiveness of the vaccine are key elements in their rejection.
Protein-Tyrosine Phosphatase H1 Increases Breast Cancer Sensitivity to Antiestrogens by Dephosphorylating Estrogen Receptor at Tyr537
PTPH1 is identified as a novel ER phosphatase and a therapeutic potential of enhancing breast cancer sensitivity to antiestrogens through dephosphorylating ER by PTPH 1 is demonstrated.
Exploration of acute genotoxic effects and antigenotoxic potential of gambogic acid using Allium cepa assay.
New targets for old hormones: inhibins clinical role revisited.
Evidence from various emerging studies that inhibins make an important contribution to other physiological functions apart from reproduction which reveals new endocrine target organs of inhibins is described.
PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study
- T. Venkatesh, A. Shetty, S. Chakraborti, P. Suresh
- BiologyJournal of cellular physiology
- 6 September 2018
Results underscore the clinical relevance of PTPH1 expression in Indian patients and warrant additional studies to explore the importance of ubiquitously methylated promoter at specific CpG sites in upstream of the P TPH1 gene.