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Immune responses and immunopathology in acute and chronic viral hepatitis
Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical naturalExpand
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CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma.
CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers. In the present study, CD133-expressing liver cancer cells following radiation exposureExpand
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Exploiting the colloidal nanocrystal library to construct electronic devices
Assembling nanocrystal devices A wide range of materials can be grown as high-quality colloidal nanocrystals, with properties spanning from conductors to semiconductors and insulators. Although theseExpand
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Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness
Significance Hepatitis C virus (HCV) infection stimulates the production of endogenous interferons (IFNs) and the following persistent activation of interferon-stimulated genes (ISGs) in the infectedExpand
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Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A
Hepatitis C virus (HCV) utilizes autophagy to promote its propagation. Here we show the autophagy-mediated suppression of HCV replication via the endoplasmic reticulum (ER) protein SCOTIN. SCOTINExpand
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CD8α(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses.
Recent studies on T follicular helper (Tfh) cells have significantly advanced our understanding of T cell-dependent B cell responses. However, little is known about the early stage of Tfh cellExpand
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Hepatitis C Virus Entry Is Impaired by Claudin-1 Downregulation in Diacylglycerol Acyltransferase-1-Deficient Cells
ABSTRACT Diacylglycerol acyltransferase-1 (DGAT1) is involved in the assembly of hepatitis C virus (HCV) by facilitating the trafficking of the HCV core protein to the lipid droplet. Here, weExpand
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Number of mutations within CTL‐defined epitopes of the hepatitis B Virus (HBV) core region is associated with HBV disease progression
The virologic determinants of progressive liver disease associated with hepatitis B virus (HBV) remain unclear. Previous investigations have associated HBV disease with specific mutations but thisExpand
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18F–fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment
PurposeSorafenib, an oral multikinase inhibitor, is a recommended treatment option available for patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). This studyExpand
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CXCL10 is produced in hepatitis A virus-infected cells in an IRF3-dependent but IFN-independent manner
Acute hepatitis A caused by hepatitis A virus (HAV) infection is accompanied by severe liver injury in adult patients, and the liver injury is associated with the production of chemokines. Herein, weExpand
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