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Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics
Sorafenib is a novel, small-molecule anticancer compound that inhibits tumor cell proliferation by targeting Raf in the Raf/MEK/ERK signalling pathway, and inhibits angiogenesis by targeting tyrosineExpand
A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer
PurposeTo characterize the cardiovascular profile of sorafenib, a multitargeted kinase inhibitor, in patients with advanced cancer.MethodsFifty-three patients with advanced cancer received oralExpand
Sympathetic neural modulation of the immune system I. Depression of T cell immunity in vivo and in vitro following chemical sympathectomy
Chemical sympathectomy of adult mice with 6-hydroxydopamine (6-OHDA) either prior to or following epicutaneous sensitization with the trinitrophenyl (TNP) hapten decreased the delayedExpand
Long‐term weight control study I (weeks 0 to 34)
To investigate the value of anorexiant medications as an adjunct to other forms of weight control therapy, we studied 121 people in a 34‐week, double‐blind clinical trial of 60 mg extended‐releaseExpand
The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary
OBJECTIVES The effect of vardenafil, a potent and highly selective phosphodiesterase-5 (PDE5) inhibitor, on symptom-limited exercise time, time to first awareness of angina, and time to ischemicExpand
Adrenergic receptors on cerebral microvessels: pericyte contribution.
R224-R230, 1989.--[125I]iodocyanopindolol ([125I]ICYP) and [3H]rauwolscine were used to quantitate, respectively, the beta- and alpha 2-adrenergic receptors in freshly isolated bovine cerebralExpand
Decreased beta-adrenergic receptors in rat heart in streptozotocin-induced diabetes: role of thyroid hormones.
The effect of streptozotocin-induced diabetes on the beta-adrenergic receptor-coupled adenylate cyclase was studied in rat heart particulate fractions. Streptozotocin treatment decreased the numberExpand
Effect of High‐Fat Breakfast and Moderate‐Fat Evening Meal on the Pharmacokinetics of Vardenafil, an Oral Phosphodiesterase‐5 Inhibitor for the Treatment of Erectile Dysfunction
The effects of food on the pharmacokinetics of vardenafil were examined in 25 healthy adult males. Single‐dose vardenafil 20 mg was administered in a randomized four‐way crossover design after anExpand
Long‐term weight control study III (weeks 104 to 156)
Between weeks 104 and 156 we attempted to optimize response by adjusting the doses of fenfluramine and phentermine. Dosing changes were based on an algorithm that aimed to achieve 120% of ideal bodyExpand
Long‐term weight control study IV (weeks 156 to 190)
To assess continued efficacy of anorexiants after 3 years of use, 52 participants (43% of those starting) entered a second double‐blind trial to compare 60 mg sustained‐release fenfluramine plus 15Expand