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In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9-t-Butylglycylamido Derivative of Minocycline (GAR-936)
ABSTRACT The 9-t-butylglycylamido derivative of minocycline (TBG-MINO) is a recently synthesized member of a novel group of antibiotics, the glycylcyclines. This new derivative, like the firstExpand
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In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines.
N,N-Dimethylglycylamido (DMG) derivatives of minocycline and 6-demethyl-6-deoxytetracycline are new semisynthetic tetracyclines referred to as the glycylcyclines. The in vitro activities of theExpand
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In Vitro and In Vivo Activities of Tigecycline (GAR-936), Daptomycin, and Comparative Antimicrobial Agents against Glycopeptide-Intermediate Staphylococcus aureus and Other Resistant Gram-Positive
ABSTRACT Tigecycline (GAR-936) and daptomycin are potent antibacterial compounds in advanced stages of clinical trials. These novel agents target multiply resistant pathogenic bacteria. Daptomycin isExpand
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Tetracycline analogs affecting binding to Tn10-Encoded Tet repressor trigger the same mechanism of induction.
We examined the influence of substituents in tetracycline (tc) analogs modified at positions 2 and 4-9 and anhydrotetracycline (atc) on induction of the Tn10-encoded Tet repressor (TetR) by aExpand
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Recent developments in tetracycline antibiotics.
The rapid emergence of pathogenic bacteria resistant to tetracyclines and other currently available antibiotics has caused serious concern among medical professionals. It has heightened resurgentExpand
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Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines.
This report describes the discovery of a new generation of tetracycline antibacterial agents, the "glycylcyclines". These agents are notable for their activity against a broad spectrum ofExpand
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Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
The tetracycline analog 9-(N, N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline (9glyTc) belongs to a new group of tetracyclines called glycylcyclines. They are strong antibiotics showingExpand
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Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety.
Racemic analogues of platelet activating factor (PAF) in which the methylene bridge separating the phosphate and trimethylammonium moieties is altered in length (7a-f) have been prepared. IncreasingExpand
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Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.
  • P. Sum, P. Petersen
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 17 May 1999
A number of new glycylcyclines were synthesized for structure-activity relationship study. Many of the derivatives exhibit potent, broad spectrum antibacterial activity against both tetracyclineExpand
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Regularization Parameter Selection for Faulty Neural Networks
A method of recovering the heading of a terrestrial vehicle navigation system having a GPS receiver integrated with a dead reckoning system using Doppler information from a single GPS satellite. Expand
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