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Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis*
TLDR
The structural differences between human APOE3 and mouse ApoE proteins are sufficient to cause an increased susceptibility to dietary-induced hypercholesterolemia and atherosclerosis in the 3/3 mice. Expand
27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
TLDR
It is shown that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metastasis in mouse models of breast cancer. Expand
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
TLDR
It is demonstrated that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-β pathology. Expand
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration.
TLDR
The findings in this model implicate the human apoE E4 allele as a susceptibility gene for AMD and support the hypothesis that common pathogenic mechanisms may underlie AMD and Alzheimer's disease. Expand
Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
TLDR
The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor. Expand
Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
TLDR
It appears that post-translational mechanisms influence the levels of apoE protein in brain, resulting in early and dramatic apo E isoform-dependent effects on brain Aβ levels that increase with age. Expand
Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model
TLDR
It is demonstrated that, once Aβ fibrillogenesis occurs, apoE4 favors the formation of CAA over parenchymal plaques and suggest that molecules or treatments that increase the ratio of Aβ 40:42 may favor the formationof CAA versus paren chymic plaques. Expand
Apo E structure determines VLDL clearance and atherosclerosis risk in mice.
TLDR
Differences solely in apo E protein structure are sufficient to cause alterations in VLDL residence time and atherosclerosis risk in mice, demonstrating a direct and highly significant correlation between V LDL clearance rate and mean atherosclerotic plaque size. Expand
The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice*
TLDR
It is found that the low density lipoprotein receptor (LDLR) regulates the cellular uptake and central nervous system levels of astrocyte-derived apoE, and the increase in murine apOE caused by LDLR deficiency was not sufficient to affect Aβ levels or deposition by 10 months of age in PDAPP mice. Expand
Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks
TLDR
The apoE4-TR mice provide an excellent model for understanding the mechanisms underlying apo E4-dependent susceptibility to cognitive decline, and deficits in both spatial and avoidance memory tasks may be related to the anatomical and functional abnormalities previously reported in the hippocampus and the amygdala of these mice. Expand
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