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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
TLDR
The extent to which common genetic variation underlies the risk of schizophrenia is shown, using two analytic approaches, and the major histocompatibility complex is implicate, which is shown to involve thousands of common alleles of very small effect.
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Genetic epidemiology of major depression: review and meta-analysis.
TLDR
A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error.
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
TLDR
Clonal hematopoiesis with somatic mutations is readily detected by means of DNA sequencing, is increasingly common as people age, and is associated with increased risks of hematologic cancer and death.
Integrative approaches for large-scale transcriptome-wide association studies
TLDR
A powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits is introduced.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
TLDR
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
TLDR
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Meta-analysis of the heritability of human traits based on fifty years of twin studies
TLDR
This study provides the most comprehensive analysis of the causes of individual differences in human traits thus far and will guide future gene-mapping efforts.
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies.
TLDR
Despite evidence of heterogeneity across studies, meta-analytic results from 12 published twin studies of schizophrenia are consistent with a view of schizophrenia as a complex trait that results from genetic and environmental etiological influences.
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