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Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.
TLDR
Pulse‐chase and immunofluorescence analyses demonstrated that proregion removal occurs in the endoplasmic reticulum and that cleavage may be required for exist from this compartment, and it is shown that pro region removal is necessary but not sufficient for enzyme activation. Expand
Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1
TLDR
It is suggested that PI3-K may be required for the signals initiated by TrkA internalization and demonstrate that specific endocytic events may distinguish ERK signaling via Rap1 and Ras. Expand
A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation
TLDR
It is demonstrated that GMP-140 is an alpha-granule membrane protein that is expressed on the platelet plasma membrane during degranulation. Expand
Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells
TLDR
Genetic proof is provided that a bacterial pathogen, N. meningitidis, can use antigenic variation to modulate their degree of virulence by performing allelic exchanges of the pilE locus between low‐and high‐adhesive isolates. Expand
Redistribution of alpha-granules and their contents in thrombin- stimulated platelets
TLDR
Thrombin stimulation of platelets causes at least some of the fibrinogen, beta TG, and PF4 stored in their alpha granules to be redistributed to their plasma membranes by way of surface-connected vacuoles formed by fusion of thealpha granules with elements of the surface- connected canalicular system. Expand
Biological and biochemical characteristics of murine megakaryoblastic cell line L8057.
TLDR
The L8057 cell line provides a potentially superior model with which to study the characteristics of megakaryocytic biology, differentiation and biochemistry and TPA increased the expression of GP IIb/IIIa, fibronectin and factor VIII:RAg. Expand
Organization of the cytoskeleton in resting, discoid platelets: preservation of actin filaments by a modified fixation that prevents osmium damage
TLDR
The ease with which single actin filaments can be seen in the dense cytoplasm of the human platelet after lysine/aldehyde fixation suggests the great potential of this new fixative for other cells. Expand
Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs*
TLDR
It is shown that the endocytosis of identical receptors could be saturated, but a complete lack of competition exists between the transferrin receptor (TfR), the low-density lipoprotein receptor, and the epidermal growth factor receptor. Expand
A role for cyclin D3 in the endomitotic cell cycle
TLDR
While the model supports a key role for cyclin D3 in the endomitotic cell cycle, it also points to the unique role of Mpl ligand in priming megakaryocytes towards platelet fragmentation. Expand
Rapid redistribution of clathrin onto macrophage plasma membranes in response to Fc receptor-ligand interaction during frustrated phagocytosis
TLDR
It is determined that macrophages cultured on BSA-coated coverslips for 24 h already have abundant surface clathrin, and a 2.6-fold increase in assembledClathrin was observed on the adherent plasma membrane of cells on immune complexes as compared with cells on B SA alone. Expand
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