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Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.
High levels of procoagulant endothelial microparticles are present in the circulating blood of patients with ACS and may contribute to the generation and perpetuation of intracoronary thrombi. Expand
Interleukin-10 inhibits intimal hyperplasia after angioplasty or stent implantation in hypercholesterolemic rabbits.
The potent attenuation of in-stent intimal growth by rhu IL-10 and its favorable toxicity profile suggest that rhuIL-10 may be useful in the prevention of in -stent restenosis. Expand
Adenovirus-mediated arterial gene therapy for restenosis: problems and perspectives.
Despite substantial progress, major technical issues, including the toxicity of first-generation adenoviral vectors, inefficient transduction of atherosclerotic arteries, and the risk of extra-arterial transfection remain to be addressed before gene therapy is applied to clinical restenosis. Expand
Pre-treatment with elastase improves the efficiency of percutaneous adenovirus-mediated gene transfer to the arterial media
Preincubation with elastase increased transduction efficiency of catheter-based gene delivery of replication-defective adenoviral vectors to rabbit iliac arteries without detectable arterial damage. Expand
Prevention of restenosis after coronary angioplasty: towards a molecular approach?
Clinical application of a molecular approach to prevent restenosis will require close collaboration between physicians, molecular biologists, and bio‐engineers. Expand
Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.
In this model, oral treatment with naroparcil appears to preserve the arterial lumen and reduce intimal thickness after arterial injury in the hypercholesterolemic rabbit. Expand
Improved efficiency of percutaneous adenoviral-mediated arterial gene transfer by pre-treatment with elastase
[Gene therapy of restenosis].
Clinical application of preventive gene therapy for gene restenosis cannot be envisioned until studies are available proving that the delivery methods (transfer vectors or local delivery systems) are completely safe, and that the candidate genes are effective in "realistic" models. Expand
[Measurement of coronary reserve by high-frequency transthoracic Doppler ultrasonography: indications and results].
- A. Scheublé, L. Feldman, É. Brochet, A. Vahanian, P. Steg
- Archives des maladies du coeur et des vaisseaux
- 1 June 2003
High-frequency transthoracic Doppler echocardiography constitutes one of the only available and simple means to evaluate microcirculatory disorders (hypertension, diabetes,...). Expand