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Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment.
TLDR
MATS analysis showed that a multicomponent vaccine could protect against a substantial proportion of invasive MenB strains isolated in Europe, however, monitoring of antigen expression will be needed in the future. Expand
Antigenic variants in Bordetella pertussis strains isolated from vaccinated and unvaccinated children.
TLDR
Compared the frequencies of Prn and PT S1 subunit variants in strains isolated from unvaccinated children, and from children vaccinated with two acellular and one whole-cell pertussis vaccine, it is suggested that Prn1 strains are more affected by vaccine-induced immunity than Prn2 and Prn3 strains. Expand
Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey
TLDR
This work provides the first use of joint analysis of WGS and epidemiological data in an international programme for regional surveillance of sexually transmitted infections and provides a framework for genomic surveillance of gonococci through standardised sampling, use of W GS, and a shared information architecture for interpretation and dissemination. Expand
Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic
TLDR
The COVID-19 infection in Italy emerged with a clustering onset similar to the one described in Wuhan, China and likewise showed worse outcomes in older males with comorbidities, supporting the importance of combined non-pharmacological control measures. Expand
Significant Gene Order and Expression Differences in Bordetella pertussis Despite Limited Gene Content Variation
TLDR
A detailed picture is provided of a pathogenic species with little gene loss or gain but with the capacity to generate variation by rearranging its chromosome and altering gene expression, which has broad implications for host adaptation by microbial pathogens. Expand
Bordetella pertussis Inhibition of Interleukin-12 (IL-12) p70 in Human Monocyte-Derived Dendritic Cells Blocks IL-12 p35 through Adenylate Cyclase Toxin-Dependent Cyclic AMP Induction
TLDR
The present study suggests that ACT-dependent cAMP induction leads to the inhibition of pathways ultimately leading to IL-12 p35 production, thus representing a mechanism for B. pertussis to escape the host immune response. Expand
Bordetella parapertussis Infection in Children: Epidemiology, Clinical Symptoms, and Molecular Characteristics of Isolates
TLDR
Children affected by B. parapertussisinfections showed a less severe clinical picture both in the duration of symptoms and in the percentage of patients affected, even when compared with vaccinated children with pertussis. Expand
Reactogenicity and immunogenicity at preschool age of a booster dose of two three-component diphtheria-tetanus-acellular pertussis vaccines in children primed in infancy with acellular vaccines.
TLDR
A booster dose of DTaP at preschool age in children primed with the same acellular pertussis vaccine is safe and immunogenic, however, the frequency of local reactions is higher than that following primary immunization and with that following booster with DT only, and parents should be informed of the potential for these reactions to occur. Expand
Vaccine coverage and determinants of incomplete vaccination in children aged 12–23 months in Dschang, West Region, Cameroon: a cross-sectional survey during a polio outbreak
TLDR
Vaccination coverage was high; however, 1 out of 7 children was partially vaccinated, and1 out of 4 did not complete timely the recommended vaccinations, and the estimated OPV-3 coverage is reassuring in relation to the ongoing polio outbreak. Expand
Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
TLDR
Analysis of the genomes of 343 B. pertussis isolates from around the world over the last 100 years suggests that the organism has emerged within the last 500 years, consistent with historical records, and shows that global transmission of new strains is very rapid and that the worldwide population of B.pertussis is evolving in response to vaccine introduction, potentially enabling vaccine escape. Expand
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