The C-Glycosylation of Flavonoids in Cereals*♦
- Melissa Brazier-Hicks, K. Evans, Markus C. Gershater, H. Puschmann, P. Steel, R. Edwards
- Chemistry, BiologyJournal of Biological Chemistry
- 1 May 2009
These results demonstrate that cereal crops synthesize C-glucosylated flavones through the concerted action of a CGT and dehydratase acting on activated 2-hydroxyflavanones, as an alternative means of generating flavonoid metabolites.
Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds
- I. Cummins, David J Wortley, R. Edwards
- BiologyProceedings of the National Academy of Sciences
- 25 March 2013
A central role for specific GSTFs in MHR in weeds that has parallels with similar roles for unrelated GSTs in MDR in humans and shows their potential as targets for chemical intervention in resistant weed management is demonstrated.
Xenobiotic Responsiveness of Arabidopsis thaliana to a Chemical Series Derived from a Herbicide Safener*
- M. Skipsey, K. Knight, Melissa Brazier-Hicks, D. Dixon, P. Steel, R. Edwards
- ChemistryJournal of Biological Chemistry
- 21 July 2011
Transcriptome studies suggested several linkages between the XR and oxidative and oxylipin signaling, confirming links with abiotic stress signaling, and suppression of glutathione content enhanced GST induction by fenclorim, whereas fatty acid desaturase mutants, which were unable to synthesize oxylIPins, showed an attenuated XR.
The chemistry and biology of LL-37.
- Matthew F. Burton, P. Steel
- BiologyNatural product reports (Print)
- 20 November 2009
This review summarises how molecular structure influences the balance between the immunomodulatory and antimicrobial functions of LL-37.
Catabolism of Glutathione Conjugates in Arabidopsis thaliana
- Melissa Brazier-Hicks, K. Evans, Oliver D Cunningham, David R. W. Hodgson, P. Steel, R. Edwards
- Biology, ChemistryJournal of Biological Chemistry
- 25 July 2008
The results reveal the surprisingly complex set of competing catabolic reactions acting on xenobiotics entering the S-glutathionylation pathway in plants, which can result in both detoxification and bioactivation.
Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase.
- I. Cummins, K. McAuley, R. Edwards
- BiologyJournal of Molecular Biology
- 2 June 2006
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.
- J. G. Mina, Ssu-Ying Pan, P. Denny
- Biology, ChemistryMolecular and biochemical parasitology (Print)
- 1 November 2009
Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase
- J. G. Mina, Y. Okada, P. Denny
- Biology, Environmental SciencePlant Molecular Biology
- 23 March 2010
All three predicted Arabidopsis IPC synthases are functionally analysed, confirming them as aureobasidin A resistant AUR1p orthologues, and expression profiling revealed that the genes encoding these orthologue are differentially expressed in various tissue types isolated fromArabidopsis.
Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity
- Melissa Brazier-Hicks, K. Knight, J. Sellars, P. Steel, R. Edwards
- ChemistryPest Management Science
- 6 February 2018
The design of safeners based on the characteristics of oxylipins proved successful in deriving compounds that invoke a rapid XR in Arabidopsis but not in providing classical safening in a cereal.
Copper-boryl mediated organic synthesis.
- D. Hemming, Russell G Fritzemeier, S. Westcott, W. Santos, P. Steel
- ChemistryChemical Society Reviews
- 1 October 2018
In this review, methodologies in copper-boryl chemistry are discussed and the many different transformations possible are surveyed.
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