P. Sperling

Publications46
h-index27
Citations2,752
Highly Influential Citations129
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The evolution of desaturases.
Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesiss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains an additional…
TLDR
DHA synthesis in stearidonic acid-fed yeast is successfully implemented by coexpression of the Δ6- and Δ5-elongases from T. tauri and O. pseudonana with the Δ5 and Δ4-desaturases from two other algae.
A Sphingolipid Desaturase from Higher Plants
TLDR
A recently cloned cDNA from sunflower codes for a fusion protein composed of an N-terminal cytochromeb 5 and a domain similar to membrane-bound acyl lipid desaturases that is a new member of the cytochrome b 5superfamily.
Plant sphingolipids: structural diversity, biosynthesis, first genes and functions.
Spatial and temporal regulation of three different microsomal oleate desaturase genes (FAD2) from normal-type and high-oleic varieties of sunflower (Helianthus annuus L.)
TLDR
The results suggest that the high-oleic mutation in sunflower interferes with the regulation of the transcription of the seed-specific FAD2 gene.
A Higher Plant Δ8 Sphingolipid Desaturase with a Preference for (Z)-Isomer Formation Confers Aluminum Tolerance to Yeast and Plants[C][OA]
TLDR
Analysis of the fatty acids and sphingobases of the transgenic yeast and plant cells demonstrated that S851 encodes the first Δ8 sphingolipid desaturase to be identified in higher plants with a preference for the 8(Z)-isomer, which indicates that changes in the sphingOLipid composition of cell membranes can protect plants from aluminum stress.
Desaturases fused to their electron donor
TLDR
A look at crystallized or computer-simulated models involving fused or free cytochrome b 5 helps to outline the problems encountered by optimizing the docking of partners and the exchange of electrons between domains of different degrees of mobility.
Identification of Fungal Sphingolipid C9-methyltransferases by Phylogenetic Profiling*
TLDR
A bioinformatics strategy was developed to identify the gene responsible for the biosynthesis of this C9-methyl group in fungal glucosylceramides and showed highest sequence similarity to plant and bacterial cyclopropane fatty acid synthases.
Identification and Characterization of a Sphingolipid Δ4-Desaturase Family*
TLDR
It is suggested that Δ4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during Drosophila sperMatogenesis.
Are glucocerebrosides the predominant sphingolipids in plant plasma membranes?
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