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The evolution of desaturases.
Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesiss⃞s⃞ The online version of this article (available at http://www.jlr.org) contains an additional
DHA synthesis in stearidonic acid-fed yeast is successfully implemented by coexpression of the Δ6- and Δ5-elongases from T. tauri and O. pseudonana with the Δ5 and Δ4-desaturases from two other algae.
A Sphingolipid Desaturase from Higher Plants
A recently cloned cDNA from sunflower codes for a fusion protein composed of an N-terminal cytochromeb 5 and a domain similar to membrane-bound acyl lipid desaturases that is a new member of the cytochrome b 5superfamily.
Spatial and temporal regulation of three different microsomal oleate desaturase genes (FAD2) from normal-type and high-oleic varieties of sunflower (Helianthus annuus L.)
The results suggest that the high-oleic mutation in sunflower interferes with the regulation of the transcription of the seed-specific FAD2 gene.
A Higher Plant Δ8 Sphingolipid Desaturase with a Preference for (Z)-Isomer Formation Confers Aluminum Tolerance to Yeast and Plants[C][OA]
Analysis of the fatty acids and sphingobases of the transgenic yeast and plant cells demonstrated that S851 encodes the first Δ8 sphingolipid desaturase to be identified in higher plants with a preference for the 8(Z)-isomer, which indicates that changes in the sphingOLipid composition of cell membranes can protect plants from aluminum stress.
Desaturases fused to their electron donor
A look at crystallized or computer-simulated models involving fused or free cytochrome b 5 helps to outline the problems encountered by optimizing the docking of partners and the exchange of electrons between domains of different degrees of mobility.
Identification of Fungal Sphingolipid C9-methyltransferases by Phylogenetic Profiling*
A bioinformatics strategy was developed to identify the gene responsible for the biosynthesis of this C9-methyl group in fungal glucosylceramides and showed highest sequence similarity to plant and bacterial cyclopropane fatty acid synthases.
Identification and Characterization of a Sphingolipid Δ4-Desaturase Family*
It is suggested that Δ4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during Drosophila sperMatogenesis.