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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Single-cell expression profiles of melanoma Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh et al. used single-cellExpand
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Timing and checkpoints in the regulation of mitotic progression.
Accurate chromosome segregation relies on the precise regulation of mitotic progression. Regulation involves control over the timing of mitosis and a spindle assembly checkpoint that links anaphaseExpand
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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein concentrations. In mammalian cells, protein levels also vary and individual cells differ widely in theirExpand
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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
The mitotic checkpoint protein hsMad2 is required to arrest cells in mitosis when chromosomes are unattached to the mitotic spindle. The presence of a single, lagging chromosome is sufficient toExpand
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Quantitative analysis of pathways controlling extrinsic apoptosis in single cells.
Apoptosis in response to TRAIL or TNF requires the activation of initiator caspases, which then activate the effector caspases that dismantle cells and cause death. However, little is known about theExpand
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Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation
Heat shock promoters contain one or more binding sites for a specific heat shock factor (HSF). We report the cloning and sequence of the gene encoding yeast HSF, and demonstrate that HSF is requiredExpand
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Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, itExpand
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Molecular Analysis of Kinetochore-Microtubule Attachment in Budding Yeast
The complex series of movements that mediates chromosome segregation during mitosis is dependent on the attachment of microtubules to kinetochores, DNA-protein complexes that assemble on centromericExpand
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Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges
Background Systems biology has embraced computational modeling in response to the quantitative nature and increasing scale of contemporary data sets. The onslaught of data is accelerating asExpand
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Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins
BackgroundKinetochores are large multi-protein structures that assemble on centromeric DNA (CEN DNA) and mediate the binding of chromosomes to microtubules. Comprising 125 base-pairs of CEN DNA andExpand
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