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Neuroprotection by Caffeine and A2A Adenosine Receptor Inactivation in a Model of Parkinson's Disease
TLDR
A potential neural basis for the inverse association of caffeine with the development of PD is established and the potential of A(2A) antagonists as a novel treatment for this neurodegenerative disease is enhanced.
Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents.
TLDR
It is demonstrated that hyperthermia per se contributes to but is not solely responsible for the METH-induced neuropathology, and studies with reserpine, a compound which dramatically lowers core temperature, demonstrated that the hypothermic state produced in the reserpinized mice did not provide protection from Meth-induced toxicity.
Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP‐Induced Parkinsonism: Sparing of Calbindin‐D25k—Containing Cells a
TLDR
The data suggest that PD and MPTP both destroy the same population of midbrain DA neurons within nuclei A8, A9, and A10, and that perhaps CaBP protects the DA neurons from cell death caused by both PD andMPTP.
Animal models of Parkinson’s disease progression
TLDR
This review critically evaluates in vivo models and the roles they play in mimicking the progression of PD and indicates that toxin-induced and genetically manipulated models are critical for the development of neuroprotective strategies.
Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.
TLDR
The results suggest that, unlike nicotine, lobeline increases DA release by potent inhibition of DA uptake into synaptic vesicles, and a subsequent alteration in presynaptic DA storage.
Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.
TLDR
MK-801, phencyclidine, and ketamine, noncompetitive antagonists of one subtype of excitatory amino acid receptor, the N-methyl-D-aspartate receptor, provided substantial protection against neurotoxicity produced by methamphetamine but not that produced by MPTP.
Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine-induced changes in monoamine systems.
TLDR
Dopaminergic action on both D1 and D2 receptors are associated with the effects of METH on the dopaminergic system, and dopamine action on D1, but not on D2, receptors appears to be involved in the effects on the serotonergic systems of the neostriatum and the cerebral cortex.
Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment
TLDR
This study provides the first evidence for concurrent formation of lipid and protein markers of oxidative stress in several brain regions of mice that are severely affected by large neurotoxic doses of METH.
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