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Elevated globotriaosylsphingosine is a hallmark of Fabry disease
It is shown that globotriaosylsphingosine is an inhibitor of α-galactosidase A activity and the increased intima-media thickness in Fabry patients therefore may be related to the presence of this metabolite. Expand
Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity
The results indicate that phosphatidylserine—and presumably its polarization—are required for optimal Cdc42 targeting and activation during cell division and mating. Expand
Software tools for analysis of mass spectrometric lipidome data.
New software tools for quantitative analysis of mass spectrometric lipidome data make accurate, high-throughput analysis of extensive sample sets feasible and are made available to the scientific community free of charge. Expand
Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
This study reports the identification of an SMS1-related (SMSr) enzyme, which catalyses the synthesis of the SM analogue ceramide phosphoethanolamine (CPE) in the ER lumen, and establishes SMSr as a key regulator of ceramide homeostasis that seems to operate as a sensor rather than a converter of ceramides in theER. Expand
Mechanisms of glycerophospholipid homeostasis in mammalian cells.
The key features of the processes contributing to phospholipid homeostasis in mammalian cells are reviewed, with a particular emphasis on the regulation and coordination of biosynthesis and degradation. Expand
Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells*
It is shown that SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively, indicating that the biological role of SM synthase goes beyond formation of SM. Expand
Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes
Phagocytes spontaneously ruffle as they probe their environment and take up antigens. These cells are uniquely enriched in phosphatidic acid, which is necessary for ruffling and macropinocytosis.
Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.
The results provide evidence for the partial contribution of the Golgi complex to the transport of newly synthesized cholesterol to the cell surface and suggest that detergent-resistant membranes are involved in the process. Expand
The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion.
Phospholipid transfer protein mediates conversion of high-density lipoprotein (HDL3) to large particles, with concomitant release of apolipoprotein A-I (apoA-I), and a model for PLTP-mediated enlargement of HDL particles is presented. Expand
Membrane Binding Mechanism of an RNA Virus-capping Enzyme*
Mutation W259A altered the mode of bilayer association of the peptide and abolished its ability to compete for membrane association of intact NSp1, demonstrating its crucial role in the membrane association and function of Nsp1. Expand