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Streptozotocin-induced diabetes in the spontaneously hypertensive rat.
Spontaneously hypertensive rats (SHR) were more sensitive to the diabetogenic effects of streptozotocin than normotensive Wistar-Kyoto (WKY) rats. Thus, 10 days after intravenous administration of 25Expand
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THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.
  • P. Somani, Bert Lum
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 February 1965
Pronethalol and N-isopropyl- p -nitrophenyl-ethanolamine (INPEA) were found to antagonize the inotropic and chronotropic actions of epinephrine and isoproterenol as well as the vasodilator action ofExpand
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The effect of inhaled verapamil on resting bronchial tone and airway contractions induced by histamine and acetylcholine in normal and asthmatic subjects.
In man, the influence of calcium entry blockers (CEB) on nonspecific bronchial sensitivity and resting bronchial tone is controversial. In 10 asthmatic and 8 normal subjects we recorded specificExpand
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Evaluation of amiodarone free radical toxicity in rat hepatocytes.
The possible roles of free radicals and lipid peroxidation in the mechanism of toxicity of amiodarone (AD) [2-butyl-3-(3',5'-diiodo-4' alpha-diethylaminoethoxybenzoyl)benzofuran] and its principleExpand
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Unidirectional absorption of gentamicin from the peritoneum during continuous ambulatory peritoneal dialysis
Gentamicin kinetics were determined after intravenous or intraperitoneal injection in five patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Our objective was to determine rate ofExpand
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Characterization of the Coronary Vasodilator and Hemodynamic Actions of Monensin, A Carboxylic Ionophore
The effects of monensin on coronary blood flow (CBF) and other hemodynamic parameters were studied in anesthetized dogs. A dose-response relationship was established, and it was found that the lowestExpand
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Antiarrhythmic effects of flecainide
  • P. Somani
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1 April 1980
A new class I antiarrhythmic, flecainide, was investigated in 10 patients to assess short‐term efficacy and safety. All patients were hospitalized for 3 days; no antiarrhythmics were given on days 1Expand
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Nutritional circulation in the heart. 3. Effect of isoproterenol and beta adrenergic blockade on myocardial hemodynamics and rubicium-86 extraction in the isolated supported heart preparation.
In the isolated supported heart preparation, an intracoronary infusion of 0.05 or 0.1 µg/min of isoproterenol produced a significant increase in heart rate, left ventricular contractile force, leftExpand
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Amiodarone and Desethylamiodarone Toxicity in Isolated Hepatocytes in Culture 1
Abstract Amiodarone, a class III antiarrhythmic drug, has been found to be effective in the management of patients with life-threatening ventricular arrhythmias. Recent reports describe the presenceExpand
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Ceftizoxime elimination kinetics in continuous ambulatory peritoneal dialysis
We investigated the kinetics of ceftizoxime, a β‐lactamase stable cephalosporin, in eight subjects undergoing continuous ambulatory peritoneal dialysis (CAPD). A single 500‐mg or 1‐gm dose wasExpand
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